{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:40:49Z","timestamp":1778841649832,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,8,10]],"date-time":"2007-08-10T00:00:00Z","timestamp":1186704000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Menopause and hypertension independently alter cardiovascular remodelling, but little is known about their effect on left ventricular and aortic wall remodelling. Eight\u2010weeks\u2010old Wistar rats were divided into four groups of six animals each: Sham group, OVX group (ovariectomized rats), 2K1C (two\u2010kidneys, one\u2010clip rats) and OVX\u2003+\u20032K1C group and kept until 19\u2003weeks. Blood pressure (BP) increased 12% in OVX group, 35% in 2K1C and OVX\u2003+\u20032K1C groups compared with sham group. Vaginal cytology showed Sham and 2K1C rats cycling normally, whereas OVX and OVX\u2003+\u20032K1C rats were persistently in dioestrus or proestrus. At euthanasia, left ventricle (LV) and thoracic aorta were removed and analysed (immunohistochemistry and stereology). LV mass\/tibia length ratio and cross\u2010sectional area of cardiomyocytes increased in all groups except Sham. The intramyocardial vascularization reduced 30% in comparison with Sham group, with no difference among OVX, 2K1C and OVX\u2003+\u20032K1C groups. The cardiac interstitium increased more than 45% in both 2K1C and OVX\u2003+\u20032K1C groups compared with Sham, but there was no significant difference between Sham and OVX groups. Nuclei number of LV cardiomyocyte diminished in OVX group, followed by 2K1C group and OVX\u2003+\u20032K1C group, with no difference between the 2K1C and the OVX\u2003+\u20032K1C groups. There was positive immunostaining for angiotensin II AT1 receptor in smooth muscle cell layer of aortic tunica media in all groups. These results show that both ovariectomy and renovascular hypertension enhance BP as a single stimulus and therefore produce adverse cardiac remodelling. However, renovascular hypertension exerts a far greater influence than surgically\u2010induced menopause in this parameter.<\/jats:p>","DOI":"10.1111\/j.1365-2613.2007.00546.x","type":"journal-article","created":{"date-parts":[[2007,8,11]],"date-time":"2007-08-11T11:02:51Z","timestamp":1186830171000},"page":"301-309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cardiac and aortic structural alterations due to surgically\u2010induced menopause associated with renovascular hypertension in rats"],"prefix":"10.1111","volume":"88","author":[{"given":"Leonardo de Souza","family":"Mendon\u00e7a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Fernandes\u2010Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Alberto","family":"Mandarim\u2010de\u2010Lacerda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gme.0000218683.97338.ea"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.02.032"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s00428-003-0775-5","article-title":"Myocyte loss in early left ventricular hypertrophy of experimental renovascular hypertension","volume":"442","author":"Buzello M.","year":"2003","journal-title":"Virchows Arch."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.34.2.217"},{"key":"e_1_2_6_6_1","first-page":"S17","article-title":"Is menopause an independent cardiovascular risk factor? 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