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A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) is a group of multifunctional proteinases. ADAMTS\u20101 and ADAMTS\u20108 have been reported to be anti\u2010angiogenic. Here, we provide evidence that ADAMTS\u20104, like ADAMTS\u20101, is expressed by endothelial cells and binds to vascular endothelial groth factor (VEGF). Moreover, ADAMTS\u20104 inhibited human dermal microvascular endothelial cells (HuDMEC) VEGF\u2010stimulated VEGF receptor (R) R2 phosphorylation, differentiation and migration, suggesting that ADAMTS\u20104 may be a novel anti\u2010angiogenic molecule.<\/jats:p>","DOI":"10.1111\/j.1365-2613.2011.00802.x","type":"journal-article","created":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T15:59:53Z","timestamp":1327075193000},"page":"70-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Anti\u2010angiogenic properties of ADAMTS\u20104 <i>in vitro<\/i>"],"prefix":"10.1111","volume":"93","author":[{"given":"Yi\u2010Ping","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn A.","family":"Staton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Buttle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012218401036"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0431-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2009.0170"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.57.121304.131306"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.13.1423"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.01.025"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1783"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65062-6"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.05.041"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(02)00007-9"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00350a005"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090655"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1520"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.22.13912"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2002.tb00307.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601400"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.005751"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.10.008"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-147-9-2409"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212964200"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003875200"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1911"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp971"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.08.014"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)31499-6"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/376062a0"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.04.047"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.00312.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214362"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2182"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.122.2.497"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.33.23349"},{"key":"e_1_2_5_34_1","first-page":"5","article-title":"The bicinchoninic acid (BCA) assay for protein quantitation","volume":"32","author":"Walker J.M.","year":"1994","journal-title":"Methods Mol. 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