{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:29:55Z","timestamp":1773293395137,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T00:00:00Z","timestamp":1330041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study analysed the initial effects of the combination of oestrogen deficiency with a calcium\u2010deficient diet on alveolar bone repair. Sixty\u2010three 3\u2010month\u2010old female rats were either ovariectomized (OVX, <jats:italic>n<\/jats:italic>\u2003=\u200342) or sham\u2010operated (SHAM, <jats:italic>n<\/jats:italic>\u2003=\u200321). Among the 42 ovariectomized rats, 21 received standard commercial food (OVX) and 21 received food with low calcium content (ESP). The mandibular first molars were extracted bilaterally 15\u2003days after ovariectomy or sham surgery. The rats were weighed and killed at 7, 21 and 45\u2003days after tooth extraction. The results were evaluated by descriptive microscopic analysis, histomorphometry of the trabecular and osteoid volume and mast cell counts. Analysis of the results indicated that trabecular volume and mast cell counts increased significantly over time, while osteoid volume decreased over time. Comparisons between the SHAM and OVX groups demonstrated no statistical differences, while comparison between the OVX and ESP groups indicated differences in trabecular volume and the number of mast cells. The data suggest that hormonal deficiency does not delay alveolar bone repair in OVX rats; however, oestrogen deficiency associated with calcium deficiency can lead to bone resorption through the activation of mast cells.<\/jats:p>","DOI":"10.1111\/j.1365-2613.2012.00809.x","type":"journal-article","created":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T18:32:29Z","timestamp":1330108349000},"page":"139-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effects of experimental osteoporosis and low calcium intake on postextraction sockets of rats"],"prefix":"10.1111","volume":"93","author":[{"given":"Renata F.","family":"d. Prado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa \u00c1. S.","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosilene F.","family":"d. Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana M. R.","family":"d. Vasconcellos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin R.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-001-1100-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1197-1209"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-199509060-00005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080871"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1891"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2006.03.004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2010.02.010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.16.e497"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.04.010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(02)00477-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199710)173:1<10::AID-JCP2>3.0.CO;2-M"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.1.188"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.07.026"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00310171"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(00)00135-7"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(96)80431-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jmicro.a023703"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-003-0433-7"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2842.2000.00542.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.262"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(90)90108-O"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(99)00032-1"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2003.10.005"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.2.229"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000016639"},{"key":"e_1_2_7_27_1","first-page":"588","volume-title":"Terap\u00eautica Cl\u00ednica","author":"Moreira C.","year":"1998"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.40.171"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(96)00309-2"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(95)00329-C"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650020617"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.11.040"},{"key":"e_1_2_7_33_1","first-page":"279","article-title":"An\u00e1lise imunoistoqu\u00edmica do col\u00e1geno III e do TGF\u2010B1 no reparo \u00f3sseo alveolar de ratas osteop\u00eanicas","volume":"24","author":"Prado R.F.","year":"2010","journal-title":"Braz. Oral Res."},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008358"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606263142605"},{"key":"e_1_2_7_36_1","first-page":"1273","volume-title":"Robbins and Cotran Pathologic Basis of Disease","author":"Rosenber A.E.","year":"2005"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jmicro.a023623"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(20000501)259:1<76::AID-AR9>3.0.CO;2-0"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0558-y"},{"key":"e_1_2_7_40_1","first-page":"318","article-title":"Efeito do tratamento com estr\u00f3genos e as isoflavonas da soja, isolados e associados, no reparo \u00f3sseo alveolar de ratas","volume":"22","author":"Silveira V.A.S.","year":"2008","journal-title":"Braz. Oral Res."},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.25.3.9084261"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0185(20010201)262:2<203::AID-AR1030>3.0.CO;2-#"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.01601.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2003.135"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1517-74912003000400002"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2004.02.013"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70308-9"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.49"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02555700"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02571317"},{"key":"e_1_2_7_51_1","first-page":"45","article-title":"Induction and pharmacological treatment of oral osteopenia in rats","volume":"48","author":"Zaffe D.","year":"1999","journal-title":"Minerva Stomatol."},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-004-0013-4"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00445.2006"}],"container-title":["International Journal of Experimental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2613.2012.00809.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2613.2012.00809.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T12:13:05Z","timestamp":1697371985000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2613.2012.00809.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,24]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1111\/j.1365-2613.2012.00809.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2613.2012.00809.x","archive":["Portico"],"relation":{},"ISSN":["0959-9673","1365-2613"],"issn-type":[{"value":"0959-9673","type":"print"},{"value":"1365-2613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,24]]},"assertion":[{"value":"2012-02-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}