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Here, we examine the effects of long\u2010term (6\u2003months) experimental diabetes on the growth of the adrenal glands; their content of phosphoribosyl pyrophosphate (PRPP); and the activity of the PRPP synthetase, G6P dehydrogenase and 6PG dehydrogenase enzymes in GH\u2010deficient dwarf rats compared to heterozygous controls. These parameters were selected in view of the known role of PRPP in both <jats:italic>de novo<\/jats:italic> and salvage pathways of purine and pyrimidine synthesis and in the formation of NAD, and in view of the role of the oxidative enzymes of the pentose phosphate pathway in both R5P formation and the generation of the NADPH that is required in reductive synthetic reactions. This study shows that GH deficiency prevents the increase in adrenal gland weight, PRPP synthetase, PRPP content and G6P dehydrogenase and 6PG dehydrogenase. This contrasts sharply with the heterozygous group that showed the expected increase in these parameters. The blood glucose levels of the groups of long\u2010term diabetic rats, both GH\u2010deficient and heterozygous, remained at an elevated level throughout the experiment. These results are fully in accord with earlier evidence from studies with somatostatin analogues which showed that the GH\u2010insulin\u2010like growth factor I (IGF\u2010I)\u2010axis plays a key role in the adrenal diabetic hypertrophy\u2010hyperfunction syndrome.<\/jats:p>","DOI":"10.1111\/j.1365-2613.2012.00818.x","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T16:03:45Z","timestamp":1337011425000},"page":"196-201","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of long\u2010term experimental diabetes on adrenal gland growth and phosphoribosyl pyrophosphate formation in growth hormone\u2010deficient dwarf rats"],"prefix":"10.1111","volume":"93","author":[{"given":"Sirilaksana","family":"Kunjara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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