{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T09:43:38Z","timestamp":1784281418518,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T00:00:00Z","timestamp":1347494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The objective of this study was to investigate the hepatoprotective effect of a bark extract of <jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>athysa cuspidata<\/jats:italic> extract (<jats:styled-content style=\"fixed-case\">BCE<\/jats:styled-content>) in a murine model of severe liver injury induced by carbon tetrachloride (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>). Forty\u2010two Wistar rats were randomized into six groups of seven animals each: <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup 1(<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>1): <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>; <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup 2 (<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>2): dimethyl sulfoxide (<jats:styled-content style=\"fixed-case\">DMSO<\/jats:styled-content>)\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>; <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup 3 (<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>3): <jats:styled-content style=\"fixed-case\">BCE<\/jats:styled-content> 400\u00a0mg\/kg alone; <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup 4 (<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4): <jats:styled-content style=\"fixed-case\">BCE<\/jats:styled-content> 200\u00a0mg\/kg\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>; <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup 5 (<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>5): <jats:styled-content style=\"fixed-case\">BCE<\/jats:styled-content> 400\u00a0mg\/kg\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>; <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup 6 (<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>6): <jats:styled-content style=\"fixed-case\">DMSO<\/jats:styled-content> alone. The extract was administered by gavage for 18\u00a0days beginning 6\u00a0days prior to the first application of <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>. After completing <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub> administration, the animals were euthanized. The animals in <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>1, <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>5 experienced significant body weight loss and had an increased liver somatic index compared with <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>3 and <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>6 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). A significant reduction in serum aspartate and alanine transaminase and gamma\u2010glutamyl transferase (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and a significant increase in the activity of the anti\u2010oxidant enzyme superoxide dismutase were found in <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>5 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Lower proportions of cellular necrosis and lipid droplets were found in the livers of animals in <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>5 compared with <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>2 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). These results confirm the marked hepatoprotective activity of the bark extract of <jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>athysa cuspidata<\/jats:italic> in severe injuries induced by <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub> in rats and suggest that this effect may be associated with the inhibition of oxidative damage.<\/jats:p>","DOI":"10.1111\/j.1365-2613.2012.00835.x","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T01:46:34Z","timestamp":1347673594000},"page":"370-376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Hepatoprotective effect of <i><scp>B<\/scp>athysa cuspidata<\/i> in a murine model of severe toxic liver injury"],"prefix":"10.1111","volume":"93","author":[{"given":"Reggiani V.","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Department of Morphology Federal University of Pelotas Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f4mulo D.","family":"Novaes","sequence":"additional","affiliation":[{"name":"Department of General Biology Federal University of Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o P. V.","family":"Leite","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Federal University of Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson F.","family":"Vilela","sequence":"additional","affiliation":[{"name":"Department Phytotechny Federal University of Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marli C.","family":"Cupertino","sequence":"additional","affiliation":[{"name":"Department of General Biology Federal University of Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edria G.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Federal University of Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio L. 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