{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:52:02Z","timestamp":1762541522580},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,4,3]],"date-time":"2006-04-03T00:00:00Z","timestamp":1144022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Apert syndrome is characterized by midface hypoplasia, syndactyly of the hands and feet, proptosis of eyes, steep and flat frontal bones, and premature union of cranial sutures. Maxillary hypoplasia, deep palatal vault, anterior open bite, crowding of the dental arch, severely delayed tooth eruption, and dental malocclusion are the main oral manifestations of this syndrome.<\/jats:p><jats:p>In this report, a case of Apert syndrome with glucose\u20106\u2010phosphate dehydrogenase (G<jats:sub>6<\/jats:sub>PD) deficiency is presented. The patient, a 4\u2010year\u2010old male and the fourth child of healthy parents, was admitted to our department because of delayed tooth eruption. He had all the cardinal symptoms of the Apert syndrome.<\/jats:p><jats:p>Clinical examination revealed that primary centrals, canines and first molars erupted; however, primary second molars and laterals had not erupted. The patient had no dental caries. Preventive treatments were applied, and subsequently, the patient was taken to long\u2010term follow up.<\/jats:p>","DOI":"10.1111\/j.1365-263x.2006.00696.x","type":"journal-article","created":{"date-parts":[[2006,4,3]],"date-time":"2006-04-03T11:18:57Z","timestamp":1144063137000},"page":"218-221","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Apert syndrome with glucose\u20106\u2010phosphate dehydrogenase deficiency: a case report"],"prefix":"10.1111","volume":"16","author":[{"given":"G.","family":"TOSUN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"SENER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,3]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320420505"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0295-165"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1217"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(96)80011-7"},{"key":"e_1_2_4_6_2","first-page":"41","article-title":"The oral manifestations of Apert syndrome","volume":"12","author":"Kreiborg S","year":"1992","journal-title":"Journal of Craniofacial Genetics and Developmental Biology"},{"key":"e_1_2_4_7_2","unstructured":"SonnenbergEM CatalanottoFA.Apert's syndrome: report of case.ASDC Journal of Dentistry for Children1977 39\u201342."},{"key":"e_1_2_4_8_2","first-page":"80","volume-title":"Atlas of the Face in Genetic Disorders","author":"Goodman RM","year":"1977"},{"key":"e_1_2_4_9_2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0094-1298(20)30823-3","article-title":"Dental, orthodontic and oral\/maxillofacial evaluation and treatment in Apert syndrome","volume":"18","author":"Ferraro NF.","year":"1991","journal-title":"Clinics in Plastic Surgery"},{"key":"e_1_2_4_10_2","first-page":"370","volume-title":"Oral Diagnosis, Oral Medicine and Treatment Planning","author":"Bricker SL","year":"1994"},{"key":"e_1_2_4_11_2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/milmed\/156.12.681","article-title":"Analgesic concerns in glucose\u20106\u2010phosphate dehydrogenase\u2010deficient dental patients: myth or reality?","volume":"156","author":"Roger EA","year":"1991","journal-title":"Military Medicine"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197809000-00009"},{"key":"e_1_2_4_13_2","first-page":"120","volume-title":"Medical Problems in Dentistry","author":"Scully C","year":"1998"},{"key":"e_1_2_4_14_2","first-page":"394","article-title":"Palatal anomalies in the syndromes of Apert and Crouzon","volume":"11","author":"Peterson JS","year":"1974","journal-title":"Cleft Palate Journal"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420080308"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00456310"},{"key":"e_1_2_4_17_2","volume-title":"Syndromes of the Head and Neck","author":"Gorlin RJ","year":"1990"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(1997)034<0117:DDIAS>2.3.CO;2"},{"key":"e_1_2_4_19_2","first-page":"35","article-title":"Regulation of organogenesis. 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