{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:09:51Z","timestamp":1783091391817,"version":"3.54.6"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,4,16]],"date-time":"2009-04-16T00:00:00Z","timestamp":1239840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p><jats:bold>Background.\u2002<\/jats:bold> Oral Langerhans cell histiocytosis is generally seen in children.<\/jats:p><jats:p><jats:bold>Objective.\u2002<\/jats:bold> To determine the clinicopathological features of oral LCH in Malaysian paediatric patients.<\/jats:p><jats:p><jats:bold>Methods.\u2002<\/jats:bold> A retrospective study was carried out to determine the clinicopathological features of Langerhans cell histiocytosis (LCH), Letterer\u2013Siwe disease, Hand\u2013Schuller\u2013Christian disease, eosinophilic granuloma, and histiocytosis X occurring in the oral cavity in children, diagnosed histologically in the main oral histopathology laboratory in Malaysia from 1967 to 2007.<\/jats:p><jats:p><jats:bold>Result.\u2002<\/jats:bold> There were 17 cases (eight girls and nine boys) with age ranging from 1 to 7\u00a0years. There were ten Malays, four Chinese, two Indians, and one of other ethnicity. Thirteen cases presented as gingival swellings with six of these cases accompanied with mobility of the teeth. Nine cases involved the mandible, two in the maxilla, and two cases in both the maxilla and mandible. The radiographic findings were mentioned only in nine cases with presence of bony erosion or destruction of the jaw bones. Four cases had punched\u2010out radiolucencies of the skull. The patients also had other systemic signs and symptoms: skin lesions (<jats:italic>n<\/jats:italic>\u00a0=\u00a05), hepatosplenomegaly (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), prolonged fever (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), diabetes insipidus (<jats:italic>n<\/jats:italic>\u00a0=\u00a01), and exophthalmos (<jats:italic>n<\/jats:italic>\u00a0=\u00a01). Two cases were known cases of systemic LCH.<\/jats:p><jats:p><jats:bold>Conclusion.\u2002<\/jats:bold> The histopathologic features of LCH are easily recognized; however, with the development of immunostaining, the use of CD1a helps in confirming the diagnosis.<\/jats:p>","DOI":"10.1111\/j.1365-263x.2009.00985.x","type":"journal-article","created":{"date-parts":[[2009,4,16]],"date-time":"2009-04-16T04:06:31Z","timestamp":1239854791000},"page":"349-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Oral Langerhans cell histiocytosis in Malaysian children: a 40\u2010year experience"],"prefix":"10.1111","volume":"19","author":[{"given":"AJURA BT ABDUL","family":"JALIL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHIN","family":"HIN\u2010LAU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,8,12]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.06.016"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2006.00683.x"},{"key":"e_1_2_8_4_2","first-page":"79","article-title":"Langerhans cell histiocytosis: a 16 year experience","volume":"83","author":"Campos MK","year":"2007","journal-title":"J"},{"key":"e_1_2_8_5_2","first-page":"149","article-title":"Oral manifestations of chronic disseminated histiocytosis. A report of 10 cases","volume":"9","author":"Minguez I","year":"2004","journal-title":"Med Oral"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-200605000-00028"},{"key":"e_1_2_8_7_2","first-page":"451","volume-title":"Oral and Maxillofacial Pathology","author":"Neville BW","year":"1995"},{"key":"e_1_2_8_8_2","first-page":"302","volume-title":"Biopsy Pathology of the Oral Tissues","author":"Odell EW","year":"1998"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.5.1241"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.2.782"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80160-0"},{"key":"e_1_2_8_12_2","first-page":"21","article-title":"Coexpression of CD1a, langerin and Birbeck's granules in Langerhans cell histiocytosis (LCH) in children: ultrastructural and immunocytochemical studies","volume":"45","author":"Dziegel P","year":"2007","journal-title":"Folia"},{"key":"e_1_2_8_13_2","first-page":"291","article-title":"Langerhans cell histiocytosis: a review of the current recommendations of the Histiocyte Society","volume":"25","author":"Satter EK","year":"2008","journal-title":"Pediatr"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2006.00802.x"}],"container-title":["International Journal of Paediatric Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-263X.2009.00985.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-263X.2009.00985.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T02:48:45Z","timestamp":1697165325000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-263X.2009.00985.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,12]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1111\/j.1365-263X.2009.00985.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-263x.2009.00985.x","archive":["Portico"],"relation":{},"ISSN":["0960-7439","1365-263X"],"issn-type":[{"value":"0960-7439","type":"print"},{"value":"1365-263X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,12]]},"assertion":[{"value":"2009-08-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}