{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:39:27Z","timestamp":1787661567686,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T00:00:00Z","timestamp":1321488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:italic>International Journal of Paediatric Dentistry 2012; 22: 239\u2013243<\/jats:italic><\/jats:p><jats:p><jats:bold>Background.\u2002<\/jats:bold> Adverse long\u2010term general and dental health effects of cancer and cancer therapy during childhood have been reported.<\/jats:p><jats:p><jats:bold>Aim.\u2002<\/jats:bold> To examine the association between chemotherapy before the age of 8 years and (1): microdontia; (2): hypodontia of premolars and permanent molars.<\/jats:p><jats:p><jats:bold>Material and methods.\u2002<\/jats:bold> In The Danish Registry of Childhood Cancer (DBCR), we identified 203 children who met the following inclusion criteria: (1) age below 8 years at the start of treatment; (2) age between 12 to 18 years upon dental examination; (3) had received chemotherapy The exclusion criterion was radiotherapy to the head and neck. A total of 150 children fulfilled the inclusion criteria. As controls, a random sample of 193 age\u2010matched unexposed children was included.<\/jats:p><jats:p><jats:bold>Results.\u2002<\/jats:bold> Microdontia was found in a total of 88 teeth in 29 (19.3%) of the 150 children who had been exposed to chemotherapy, while none of the controls had microdontia of premolars or permanent molars (difference: 19.3%; 95% CL: 13.5%; 26.4%). The earlier the exposure, the more frequent was microdontia. We found a total of 27 missing premolars and permanent molars in 14 (9.3%) of the exposed children and a total of 18 missing premolars and permanent molars in 8 (4.1%) of the controls (difference: 5.2%; 95% CL: \u22120.1%; 11.3%).<\/jats:p><jats:p><jats:bold>Conclusion.\u2002<\/jats:bold> The present study confirms findings from previous studies that chemotherapy, especially in very young children, causes microdontia and hypodontia of premolars and permanent molars.<\/jats:p>","DOI":"10.1111\/j.1365-263x.2011.01199.x","type":"journal-article","created":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T04:26:41Z","timestamp":1321590401000},"page":"239-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Microdontia and hypodontia of premolars and permanent molars in childhood cancer survivors after chemotherapy"],"prefix":"10.1111","volume":"22","author":[{"given":"LISBETH 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