{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T05:49:46Z","timestamp":1697176186293},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,30]],"date-time":"2007-03-30T00:00:00Z","timestamp":1175212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Clinical Nursing"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p><jats:bold>Aims.\u2002<\/jats:bold> The aim of this study is to determine the relationships between hostility and serum homocysteine in Korean patients with coronary artery disease and to identify their effects on the occurrence of coronary artery disease.<\/jats:p><jats:p><jats:bold>Background.\u2002<\/jats:bold> Recently, hostility as a psychosocial factor and serum homocysteine as a biochemical risk factor are gradually accepted as independent risk factors of coronary artery disease but research on the relationship between hostility and homocysteine is rare.<\/jats:p><jats:p><jats:bold>Design.\u2002<\/jats:bold> This is a descriptive and correlative study conducted in the single teaching hospital located in South Korea.<\/jats:p><jats:p><jats:bold>Methods.\u2002<\/jats:bold> Eighty\u2010four patients with coronary artery disease participated. Semi\u2010structured interviews were used to measure the level of hostility and the characteristics of participants. Hostility was measured by the Cynical Hostility Scale and fasting blood samples from venous vein was used to measure serum homocysteine level.<\/jats:p><jats:p><jats:bold>Results.\u2002<\/jats:bold> Mean scores for hostility of men were higher than women. The difference was statistically significant (<jats:italic>p<\/jats:italic>\u2003=\u20030\u00b7001). The serum homocysteine level (11\u00b751\u2003SD\u20035\u00b743\u2003<jats:italic>\u03bc<\/jats:italic>mol\/l) in patients with coronary artery disease was higher than the normal reference value. Findings of this study indicate that serum homocysteine increased in a statistically consistent pattern with the level of hostility (<jats:italic>F<\/jats:italic>\u2003=\u20038\u00b737, <jats:italic>p<\/jats:italic>\u2003&lt;\u20030\u00b701).<\/jats:p><jats:p><jats:bold>Conclusions.\u2002<\/jats:bold> This result suggests that high level of hostility may increase cardiovascular risk by elevated serum homocysteine concentration.<\/jats:p><jats:p><jats:bold>Relevance to clinical practice.\u2002<\/jats:bold> The development and applications of nursing interventions for hostility can contribute to reducing the prevalence and mortality rate of coronary artery disease.<\/jats:p>","DOI":"10.1111\/j.1365-2702.2006.01699.x","type":"journal-article","created":{"date-parts":[[2007,3,30]],"date-time":"2007-03-30T09:15:38Z","timestamp":1175246138000},"page":"672-678","source":"Crossref","is-referenced-by-count":3,"title":["Hostility and serum homocysteine as cardiovascular risk factors in Korean patients with coronary artery disease"],"prefix":"10.1111","volume":"16","author":[{"given":"Youn\u2010Jung","family":"Son","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,30]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Laboratory Medicine of Ajou Medical Hospital","author":"Ajou Medical Hospital Laboratory","year":"2003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.21.2829"},{"key":"e_1_2_8_4_1","volume-title":"Heart Disease and Stroke Statistics \u2013 2004 update","author":"American Heart Association","year":"2003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530130055028"},{"key":"e_1_2_8_6_1","volume-title":"Statistical Power Analysis for the Behavioral Science","author":"Cohen J","year":"1988"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-198603000-00014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009245"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005369109055"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.19.2546"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1093\/clinchem\/44.8.1833","article-title":"Homocysteine and vitamins in cardiovascular disease","volume":"44","author":"Jacobsen DW","year":"1998","journal-title":"Clinical Chemistry"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197604292941806"},{"key":"e_1_2_8_13_1","first-page":"79","article-title":"The effect of anger, hostility and stress on physical health","volume":"2","author":"Kim KH","year":"1997","journal-title":"Journal of Korean Psychology"},{"key":"e_1_2_8_14_1","volume-title":"The Statistics Year Book on Cause of Death","author":"Korea National Statistical Office","year":"1998"},{"key":"e_1_2_8_15_1","unstructured":"LeeDH(1996)The Effect of Hostility Task Difficulty and Social Support on Cardiovascular Reactivity.Unpublished master's thesis Chung\u2010Nam University Daejeon South Korea."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.11.5.317"},{"key":"e_1_2_8_17_1","first-page":"111","article-title":"Vascular pathology of homocysteine: implications for the pathogenesis of arteriosclerosis","volume":"56","author":"McCully KS","year":"1969","journal-title":"American Journal of Pathology"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1999.00512.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700001720"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.49.1.31"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199101000-00004"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00845355"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0191-8869(99)00222-6"},{"key":"e_1_2_8_24_1","unstructured":"SPSS Inc.(2000)Statistical Package Program for Social Science for Windows (Version 10.0). 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