{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:18:22Z","timestamp":1778689102892,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,5,22]],"date-time":"2006-05-22T00:00:00Z","timestamp":1148256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives\u2002<\/jats:bold> The objectives were (1) to report the preliminary development of the Hormone Deficiency\u2010dependent Quality of Life (HDQoL) questionnaire, a new individualized questionnaire in which respondents rate personally applicable domains for importance and impact of hormonal deficiency and its treatment; (2) to evaluate the HDQoL\u2019s psychometric properties for adults with hypopituitarism including growth hormone deficiency (GHD).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Internal consistency reliability, aspects of validity, and sensitivity to change of the HDQoL were investigated in: (1) a cross\u2010sectional survey of 157 adults with treated or untreated GHD; (2) a randomized, placebo\u2010controlled study of 3 months\u2019 growth hormone (GH) withdrawal from 12 of 21 GH\u2010treated adults.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Thirteen of the original 18 HDQoL domains were relevant and important for GH\u2010deficient adults. The shorter 13\u2010item HDQoL had excellent internal reliability (Cronbach\u2019s alpha coefficient\u2003=\u20030.914, <jats:italic>n<\/jats:italic>\u2003=\u2003109), and was sensitive to sex differences (cross\u2010sectional study): women perceived worse present QoL than men [<jats:italic>t<\/jats:italic>(149.8)\u2003=\u20032.33, <jats:italic>P<\/jats:italic>\u2003=\u20030.021]. The HDQoL was sensitive to change (GH\u2010withdrawal study) with a significant between\u2010group difference in change in domain scores for <jats:italic>things I can do physically<\/jats:italic>[<jats:italic>t<\/jats:italic>(16)\u2003=\u20032.47, <jats:italic>P<\/jats:italic>\u2003=\u20030.025, 2\u2010tailed], patients withdrawn from GH reporting greater negative impact of hormone deficiency on this domain at end\u2010point. Qualitative work resulted in the addition of seven new HDQoL domains, including energy and bodily pain.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The HDQoL, although at an early stage of development, proved useful in identifying expected changes following GH withdrawal. The extended 20\u2010item version is recommended for further evaluation in assessing the impact of hypopituitarism on QoL.<\/jats:p>","DOI":"10.1111\/j.1365-2753.2006.00659.x","type":"journal-article","created":{"date-parts":[[2006,5,22]],"date-time":"2006-05-22T14:48:20Z","timestamp":1148309300000},"page":"501-514","source":"Crossref","is-referenced-by-count":13,"title":["Preliminary development of the new individualized HDQoL questionnaire measuring quality of life in adult hypopituitarism"],"prefix":"10.1111","volume":"12","author":[{"given":"Carolyn V.","family":"McMillan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Gibney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David 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