{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:16:21Z","timestamp":1761765381493},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,1,30]],"date-time":"2011-01-30T00:00:00Z","timestamp":1296345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Rationale, aims and objectives\u2002<\/jats:bold> To test the agreement between guidelines for the management of hypertension and medical practices while avoiding frequent limitations such as the use of non\u2010representative samples of practitioners and self\u2010reporting of their practices over a short period of time.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> The characteristics of initial antihypertensive drug treatment in a large representative sample of the French population aged 50\u201380 (<jats:italic>n<\/jats:italic>\u2003=\u200317\u2003855) were collected from a national health care reimbursement database and compared with national guidelines over a 5\u2010year period.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Major discrepancies are observed including the use of non\u2010recommended drug classes such as loop and potassium sparing diuretics alone or in association and the absence of distinction between patients according to their age. More minor discrepancies are the preferential use of mono\u2010therapies over drug combinations and of some bi\u2010therapies among those recommended. Some degree of concordance with the guidelines is also observed including the specific characteristics of the treatment of diabetics compared with other categories of patients and the preferential use of long\u2010acting dihydropyridine calcium antagonists and of low\u2010dose thiazide diuretics when these drug classes are chosen. Several of these discrepancies or concordances, which mainly reflect general practitioner (GP) activity, show time trends over the entire follow\u2010up period with no significant effect of the guideline released during this period.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> At the French national level, the agreement between initial antihypertensive drug treatment and guidelines varies considerably depending on the characteristics of the treatment that are considered. The GPs who delivered the treatment do not seem to have been influenced by the guidelines released over the last decade.<\/jats:p>","DOI":"10.1111\/j.1365-2753.2011.01640.x","type":"journal-article","created":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T09:07:18Z","timestamp":1296464838000},"page":"623-629","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of the agreement between guidelines and initial antihypertensive drug treatment using a national health care reimbursement database"],"prefix":"10.1111","volume":"18","author":[{"given":"Pierre","family":"Meneton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Ricordeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Weill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Tuppin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sol\u00e8ne","family":"Samson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert","family":"Allemand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Durieux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00ebl","family":"M\u00e9nard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812313392701"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200207000-00002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/18.4.359"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000356769.32130.95"},{"key":"e_1_2_6_6_2","first-page":"9","article-title":"Blood pressure control in treated hypertensive patients: clinical performance of general practitioners","volume":"51","author":"Frijling B. 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