{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:59:57Z","timestamp":1782554397318,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,7,29]],"date-time":"2012-07-29T00:00:00Z","timestamp":1343520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2013,8]]},"abstract":"Abstract<\/jats:title>Rationale<\/jats:title>Despite the availability of various prevention guidelines on acute coronary syndrome (ACS<\/jats:styled-content>), secondary prevention practice utilizing aspirin, beta\u2010blockers, angiotensin converting enzyme inhibitors and statins still can be sub\u2010optimal.<\/jats:p><\/jats:sec>Aims and objectives<\/jats:title>To review and document the utilization of pharmacotherapy for the secondary prevention of ACS<\/jats:styled-content> in patients discharged from a M<\/jats:styled-content>alaysian hospital.<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective cross\u2010sectional study was conducted at a tertiary hospital in P<\/jats:styled-content>enang, M<\/jats:styled-content>alaysia. Patients with a primary diagnosis of ACS were identified from medical records over a 4\u2010month period. A range of clinical data was extracted from medical records, including medical history, clinical presentation and pharmacotherapy both on admission and at discharge. This audit focused on the use of four guideline\u2010recommended therapies: aspirin\u00b1clopidogrel, beta\u2010blockers, statins and angiotensin\u2010converting enzyme inhibitor (ACEI<\/jats:styled-content>)\/angiotensin II<\/jats:styled-content> receptor blockers (ARBs<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Data pertaining to a total of 380 ACS<\/jats:styled-content> patients was extracted and reviewed, the mean age of the study population was 57.49 years and 73.9% of population was males. Patients with unstable angina accounted for 56.6% of the admissions whereas 23.4% and 20% of the patients were admitted for ST\u2010elevation myocardial infarction and non\u2010ST\u2010segment elevation infarct respectively. 95.7% of the patients received antiplatelets comprising of at least aspirin, and 82% received aspirin plus clopidogrel. Furthermore, 80.3% of the patients received a beta\u2010blocker at discharge, 95% a statin and 69.7% received either an ACEI<\/jats:styled-content> or ARB<\/jats:styled-content>. Compared with patients who presented with myocardial infarction (with or without ST<\/jats:styled-content>\u2010segment elevation), those presenting with unstable angina were less likely to receive the combination of aspirin plus clopidogrel or an ACEI<\/jats:styled-content>\/ARB<\/jats:styled-content> at discharge. Patients over 65 years of age were also less likely to receive a beta\u2010blocker at discharge, compared with younger patients.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>There is a good adherence to evidence\u2010based guidelines for the secondary prevention of ACS<\/jats:styled-content> in this local setting. However, there is some potential underutilization in the older population and patients presenting with unstable angina.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2753.2012.01894.x","type":"journal-article","created":{"date-parts":[[2012,7,30]],"date-time":"2012-07-30T00:37:23Z","timestamp":1343608643000},"page":"658-663","source":"Crossref","is-referenced-by-count":8,"title":["Use of evidence\u2010based therapy for the secondary prevention of acute coronary syndromes in M<\/scp>alaysian practice"],"prefix":"10.1111","volume":"19","author":[{"given":"Yaman Walid","family":"Kassab","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy School of Pharmaceutical Sciences Universiti Sains Malaysia Pulau Pinang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahaya","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Universiti Teknologi MARA Puncak Alam Campus Bandar Puncak Alam Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noorizan Abd","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Universiti Teknologi MARA Puncak Alam Campus Bandar Puncak Alam Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadeer","family":"Akram","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy School of Pharmaceutical Sciences Universiti Sains Malaysia Pulau Pinang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Pulau Pinang Pinang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,29]]},"reference":[{"issue":"3","key":"e_1_2_7_2_1","first-page":"29","article-title":"Acute Coronary Syndrome (ACS) Registry \u2013 leading the charge for National Cardiovascular Disease (NCVD) database","volume":"63","author":"Chin S. P.","year":"2008","journal-title":"The Medical Journal of Malaysia"},{"issue":"1","key":"e_1_2_7_3_1","first-page":"228","article-title":"Seventeen\u2010month follow\u2010up of drug utilization for secondary prevention in coronary artery disease","volume":"3","author":"Kassab Y. W.","year":"2012","journal-title":"International Journal of Pharmacy Teaching & Practices"},{"key":"e_1_2_7_4_1","unstructured":"Number of discharges and deaths in government hospitals. Information and Documentation System Unit. 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