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Egg batches selected for their total VA concentration were exposed to low (normal, 8\u2003\u00b0C) or elevated (14\u2003\u00b0C) egg incubation temperatures. Temperature was the main factor causing bone deformities such as warped gill opercula, fin and jaw deformities, but not for the development of spinal deformities where all groups displayed a \u2018baseline\u2019 occurrence of mild deformity (decreased vertebral size in the cephalic region) and no systematic variation in the occurrence of serious spinal deformities (fused vertebrae). A possible effect of egg incubation temperature fluctuation was found for the groups reared at low temperatures. An indication of a negative effect of elevated egg VA status for the development of organ deformities such as missing septum transversum and situs inversus was found in addition to temperature effects, however, no firm conclusions could be drawn from the present data. The phenotypes for temperature\u2010induced deformities resembled the phenotype of VA\u2010induced deformities, but no clear conclusions on the causality of the deformities found in the present study could be drawn. Egg incubation temperatures, both absolute temperature and temperature variations, should therefore be strictly controlled.<\/jats:p>","DOI":"10.1111\/j.1365-2761.2004.00536.x","type":"journal-article","created":{"date-parts":[[2004,3,25]],"date-time":"2004-03-25T18:41:15Z","timestamp":1080240075000},"page":"213-223","source":"Crossref","is-referenced-by-count":60,"title":["Teratogenicity of elevated egg incubation temperature and egg vitamin A status in Atlantic salmon, <i>Salmo salar<\/i> L."],"prefix":"10.1111","volume":"27","author":[{"given":"R","family":"\u00d8rnsrud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Gil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Waagb\u00f8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2331\/suisan.34.959"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2331\/suisan.62.857"},{"key":"e_1_2_7_4_1","first-page":"22","volume-title":"Feilutvikling og deformiteter hos laks","author":"B\u00e6verfjord G.","year":"1998"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.1988.tb05496.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2000.tb01848.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0044-8486(88)90379-1"},{"key":"e_1_2_7_8_1","article-title":"Foodstuffs \u2013 determination of vitamin A by high performance liquid chromatography \u2013 Part 1: measurement of all\u2010trans retinol and 13\u2010cis retinol","author":"CEN","year":"1999","journal-title":"Comit\u00e8 Europ\u00e8en de Normalisation"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1242\/dev.126.12.2589","article-title":"Retinoic acid is required in the mouse embryo for left\u2013right asymmetry determination and heart morphogenesis","volume":"126","author":"Chazaud C.","year":"1999","journal-title":"Development"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000068932"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0044-8486(95)00015-T"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2331\/fishsci.63.466"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1993.1318"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420300314"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(96)00616-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2095.1995.tb00040.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000241223"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(77)90055-X"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.14430\/arctic1234"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000062660.12769.E6"},{"key":"e_1_2_7_21_1","first-page":"24","article-title":"Forekomst av \u2018korthale\u2019\u2013 en ryggradsdeformitet hos laks (in Norwegian)","volume":"8","author":"H\u00f8ie S.","year":"1996","journal-title":"Norsk Fiskeoppdrett"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1444-2906.2002.00462.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2109.2001.00567.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420450106"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0887-2333(95)00012-W"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/113.9.1737"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2331\/suisan.33.1126"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9327(78)90128-3"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0044-8486(97)89294-0"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0044-8486(01)00552-X"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3354\/dao039097"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2109.2001.00552.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003830050399"},{"key":"e_1_2_7_34_1","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1242\/dev.120.10.2749","article-title":"Function of the retinoic acid receptors (RARs) during development. 2. 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