{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T02:48:45Z","timestamp":1769050125493,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,10,9]],"date-time":"2006-10-09T00:00:00Z","timestamp":1160352000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The efficacy of emamectin benzoate (SLICE<jats:sup>\u00ae<\/jats:sup>) against sea lice infestations of Atlantic salmon, <jats:italic>Salmo salar<\/jats:italic> L., is typically assessed using untreated fish, or fish treated with alternative therapeutants, as controls. The State of Maine, USA, is currently under active management for the OIE\u2010notifiable pathogen, infectious salmon anaemia virus (ISAV); consequently, neither control group is feasible in this region. Untreated salmon risk extensive damage from the ectoparasites, and threaten to increase vector\u2010borne exposure or susceptibility of farms to ISAV; and the only treatment presently available in Maine is SLICE<jats:sup>\u00ae<\/jats:sup>. However, because sea lice infestations are unlikely to resolve spontaneously, and response to treatment occurs within weeks, use of a pretreatment baseline is a reasonable alternative for confirmatory studies. We evaluated SLICE<jats:sup>\u00ae<\/jats:sup> efficacy on Atlantic salmon farms in Cobscook Bay 2002\u20132005, in the absence of untreated controls, using pretreatment lice loads as a reference for calculation. Maximum efficacy ranged from 68% to 100% reduction from initial levels. Time\u2010to\u2010maximum efficacy ranged from 1 to 8\u2003weeks after treatment initiation. Efficacy duration, measured between first reduction and first progressive rise in counts, ranged from 4 to 16\u2003weeks.<\/jats:p>","DOI":"10.1111\/j.1365-2761.2006.00761.x","type":"journal-article","created":{"date-parts":[[2006,10,9]],"date-time":"2006-10-09T08:38:57Z","timestamp":1160383137000},"page":"621-627","source":"Crossref","is-referenced-by-count":37,"title":["Efficacy of emamectin benzoate against sea lice infestations of Atlantic salmon, <i>Salmo salar<\/i> L.: evaluation in the absence of an untreated contemporary control"],"prefix":"10.1111","volume":"29","author":[{"given":"L","family":"Gustafson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Marenghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Endris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jee\/18.2.265a"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3139(97)80020-3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0044-8486(90)90125-7"},{"key":"e_1_2_5_5_1","first-page":"24390","article-title":"International conference on harmonisation; 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