{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:09:04Z","timestamp":1791947344256,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T00:00:00Z","timestamp":1321833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This is the first pathological description of \u2018scale drop syndrome\u2019 (SDS) in Asian seabass, <jats:italic>Lates calcarifer<\/jats:italic> Bloch. Cumulative mortality was estimated at 40\u201350%. The vasculitis in all major organs including the skin and associated tissue necrosis was distinctive. The dermis overlying scale beds was often necrotic and associated with scale loss. Necrosis of splenic ellipsoids, renal glomeruli and <jats:italic>choroid rete<\/jats:italic> glands of eye were further hallmarks of a disease with systemic vascular involvement. The brain was not spared vascular damage, and the resulting multifocal encephalomalacia probably accounts for the spiral swimming behaviour in some affected fish. Other lesions included accentuated hepatic lobulation and gastric gland necrosis. Nuclear chromatin margination and karyolysis in hepatocytes, renal tubular epithelium and gastric and intestinal epithelium suggest specific targeting of cells. Basophilic cytoplasmic inclusions were present in spleen, kidney, liver, heart and <jats:italic>choroid rete,<\/jats:italic> but they were not prominent. Using transmission electron microscopy, two morphological forms of virions were observed: single\u2010 and double\u2010enveloped hexagonal virions. Based on size and morphology, these virions resemble iridovirus or herpesvirus. The cause of SDS is unknown, but the pathological changes, especially the vasculitis, suggest an infectious aetiology, possibly viral.<\/jats:p>","DOI":"10.1111\/j.1365-2761.2011.01319.x","type":"journal-article","created":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T13:16:35Z","timestamp":1321881395000},"page":"19-27","source":"Crossref","is-referenced-by-count":61,"title":["The pathology of \u2018scale drop syndrome\u2019 in Asian seabass, <i>Lates calcarifer<\/i> Bloch, a first description"],"prefix":"10.1111","volume":"35","author":[{"given":"S","family":"Gibson\u2010Kueh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Chee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y 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