{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:58:45Z","timestamp":1762505925238,"version":"3.40.3"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T00:00:00Z","timestamp":1334880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:bold>How to cite this article:<\/jats:bold>Wedlake L.J., McGough C., Shaw C., Klopper T., Thomas K., Lalji A., Dearnaley D.P., Blake P., Tait D., Khoo V.S. &amp; Andreyev H.J.N. (2012) Clinical trial: efficacy of a low or modified fat diet for the prevention of gastrointestinal toxicity in patients receiving radiotherapy treatment for pelvic malignancies.<jats:italic>J Hum Nutr Diet.<\/jats:italic><jats:bold>25<\/jats:bold>, 247\u2013259<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold>Inflammatory responses to pelvic radiotherapy can result in severe changes to normal gastrointestinal function with potentially severe long\u2010term effects. Reduced or modified fat diets may confer benefit.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>This randomised controlled trial recruited patients with gynaecological, urological or lower gastrointestinal malignancy due to receive radical radiotherapy. Patients were randomised to a low fat (20% total energy from long chain triglycerides), modified fat (20% from long chain triglycerides and 20% from medium chain triglycerides) or normal fat diet (40% total energy from long chain triglycerides). The primary outcome was a difference in change in Inflammatory Bowel Disease Questionnaire \u2013 Bowel (IBDQ\u2010B) score, from the start to end of radiotherapy.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>A total of 117 patients with pelvic tumours (48% urological; 32% gastrointestinal; 20% gynaecological), with mean (SD) age: 65 (11.0) years, male\u2003:\u2003female ratio: 79\u2003:\u200338, were randomised. The mean (SE) fall in paired IBDQ\u2010B score was \u22127.3 (0.9) points, indicating a worsening toxicity. Differences between groups were not significant:<jats:italic>P\u2003<\/jats:italic>=\u20030.914 (low versus modified fat),<jats:italic>P<\/jats:italic>\u2003=\u20030.793 (low versus normal fat) and<jats:italic>P<\/jats:italic>\u2003=\u20030.890 (modified versus normal fat). The difference in fat intake between low and normal fat groups was 29.5\u2003g [1109\u2003kJ (265\u2003kcal)] amounting to 11% (of total energy intake) compared to the planned 20% differential. Full compliance with fat prescription was only 9% in the normal fat group compared to 93% in the low fat group.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>A low or modified fat diet during pelvic radiotherapy did not improve gastrointestinal symptom scores compared to a normal fat intake. 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