{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:05:47Z","timestamp":1770476747751,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,9,19]],"date-time":"2006-09-19T00:00:00Z","timestamp":1158624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2003<\/jats:bold> Velocardiofacial syndrome (VCFS) is a microdeletion syndrome caused by a 22q11.2 chromosomal deletion.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> In this study, parents reported on their own temperament as well as the temperament of their child. Sixty\u2010seven children with VCFS (mean age\u2003=\u200310.8, SD\u2003=\u20032.8; range 6\u201315), and age\u2010, race\u2010 and gender\u2010ratio matched samples of 47 community control participants (mean age\u2003=\u200310.4, SD\u2003=\u20032.6; range 6\u201315), and 18 sibling control participants (mean age\u2003=\u200312.1, SD\u2003=\u20031.9; range 9\u201315) took part in the current project.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Children with VCFS have a temperament that may best be described as modestly difficult; while participants with VCFS were not more difficult across all temperamental domains, children with VCFS were rated by their parents as being: (1) less regular in their daily habits (e.g. eating at the same time each day, etc.); (2) less able to focus\/sustain attention; (3) less cheerful\/pleasant; (4) less likely to stay with an activity for a long time; and (5) less able to respond flexibly to changes in the environment.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> The best predictors of parent report of behavioural symptoms in children with VCFS were poor concordance between parent and child temperament across general activity level and mood domains.<\/jats:p>","DOI":"10.1111\/j.1365-2788.2006.00859.x","type":"journal-article","created":{"date-parts":[[2006,9,19]],"date-time":"2006-09-19T07:36:24Z","timestamp":1158651384000},"page":"218-227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Temperament in velocardiofacial syndrome"],"prefix":"10.1111","volume":"51","author":[{"given":"K. 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