{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T03:11:14Z","timestamp":1726283474426},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T00:00:00Z","timestamp":1162252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2003<\/jats:bold> While clozapine is an effective treatment for refractory schizophrenia, its use is limited by haematological side effects. Treatment options that allow continued prescription of clozapine by tackling these side effects will greatly aid patients for whom this medication is all too often their only hope of recovery.<\/jats:p><jats:p><jats:bold>Method\u2003<\/jats:bold> In this case report, we describe what we believe are two \u2018firsts\u2019 in the clozapine literature: the use of granulocyte\u2010colony stimulating factor on a <jats:italic>prophylactic<\/jats:italic> basis in an <jats:italic>intellectually disabled patient<\/jats:italic> receiving clozapine for refractory schizophrenia.<\/jats:p><jats:p><jats:bold>Result\u2003<\/jats:bold> Treatment with granulocyte\u2010colony stimulating factor prevented discontinuation of clozapine, enabling our intellectually disabled patient\u2019s recovery from a schizophrenic illness.<\/jats:p>","DOI":"10.1111\/j.1365-2788.2006.00865.x","type":"journal-article","created":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T14:50:27Z","timestamp":1162306227000},"page":"82-85","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Prevention of clozapine\u2010induced granulocytopenia\/agranulocytosis with granulocyte\u2010colony stimulating factor (G\u2010CSF) in an intellectually disabled patient with schizophrenia"],"prefix":"10.1111","volume":"51","author":[{"given":"G.","family":"Rajagopal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. G.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. F. A.","family":"Haut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,31]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199307153290303"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.169.4.483"},{"key":"e_1_2_4_4_1","first-page":"245","article-title":"Granulocyte\u2010macrophage colony stimulation factor (GM\u2010CSF) treatment of clozapine\u2010induced agranulocytosis: a case report","volume":"53","author":"Barnas C.","year":"1992","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199805000-00008"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(05)80058-2"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93116-5"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800330013001"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1192\/pb.29.5.186"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91625-I"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.172.1.82"}],"container-title":["Journal of Intellectual Disability Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2788.2006.00865.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2788.2006.00865.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T01:22:11Z","timestamp":1697160131000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2788.2006.00865.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,31]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1365-2788.2006.00865.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2788.2006.00865.x","archive":["Portico"],"relation":{},"ISSN":["0964-2633","1365-2788"],"issn-type":[{"value":"0964-2633","type":"print"},{"value":"1365-2788","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,31]]},"assertion":[{"value":"2006-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}