{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:39:03Z","timestamp":1791041943985,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T00:00:00Z","timestamp":1162252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2003<\/jats:bold> This study is part of a larger UK\u2010wide study investigating psychiatric illness in people with Prader\u2013Willi syndrome (PWS), and describes the longitudinal aspect of psychiatric illness, in particular psychotic illness, and examines the use and role of psychotropic medication.<\/jats:p><jats:p><jats:bold>Method\u2003<\/jats:bold> A total of 119 individuals with genetically confirmed PWS were included in the study. An informant\u2010based questionnaire was administered for each participant to screen for a history of psychopathology. Those who screened positive were visited at their homes to obtain further information. This assessment included a full psychiatric history and mental state examination using the Psychiatric Assessment Schedule for Adults with Developmental Disability and the Operational Criteria Checklist for psychotic and affective illness to collect information regarding phenomenology and course of illness, and a modified life events questionnaire. At the end of the study period, informant\u2010based telephone interviews were again carried out, up to 2.5\u2003years after the initial screening. Information regarding medication usage was collected.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> The results confirm previous findings that psychiatric illness in people with PWS resembles an affective disorder. Individuals with the maternal uniparental disomy genetic subtype had a more severe course of illness than those with the deletion genetic subtype in terms of a greater risk of recurrence, more episodes, higher incidence and a possibly poorer response to medication with more side\u2010effects. Individuals with a recurrent episode during the follow\u2010up period had a poorer course of illness. Selective serotonin reuptake inhibitor medication is frequently used, and beneficial effects may reflect fundamental pathological processes in PWS. Mood\u2010stabilizing medication was found to be of little benefit and reasons for this are examined.<\/jats:p><jats:p><jats:bold>Conclusion\u2003<\/jats:bold> The longitudinal course of psychiatric illness and response to medication in people with PWS is fully described. Further research is needed regarding the effect of psychotropic medications, particularly mood\u2010stabilizing medication. These data will enable informed decisions to be made regarding management options and provide information on the possible long\u2010term outcome of illness.<\/jats:p>","DOI":"10.1111\/j.1365-2788.2006.00895.x","type":"journal-article","created":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T14:50:27Z","timestamp":1162306227000},"page":"32-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":155,"title":["The course and outcome of psychiatric illness in people with Prader\u2013Willi syndrome: implications for management and treatment"],"prefix":"10.1111","volume":"51","author":[{"given":"S.","family":"Soni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Whittington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Webb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Maina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,31]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Abbott Laboratories Limited(2003)Reductil Summary of Product Characteristics.Abbott Laboratories Maidenhead."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00519-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.1998.4260463.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0213a"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07340-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(18)30166-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.1998.4260440.x"},{"key":"e_1_2_6_9_1","first-page":"385","article-title":"Psychotropic drugs and mental retardation: 1. Disabilities and the prescription of drugs for behaviour and for epilepsy in three residential settings","volume":"34","author":"Clarke D. J.","year":"1990","journal-title":"Journal of Mental Deficiency Research"},{"key":"e_1_2_6_10_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J.","year":"1998"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199103000-00020"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.2002.00354.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2000.102006461.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.9.1.75"},{"key":"e_1_2_6_15_1","volume-title":"Neuroregulators and Psychiatric Disorders","author":"Eichelmann B.","year":"1977"},{"issue":"4","key":"e_1_2_6_16_1","first-page":"73","article-title":"The Expert Consensus Guidelines for treating depression in bipolar disorder","volume":"59","author":"Frances A. J.","year":"1998","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_6_17_1","first-page":"245","article-title":"Self\u2010injurious behavior and serotonin in Prader\u2013Willi Syndrome","volume":"30","author":"Hellings J. A.","year":"1994","journal-title":"Psychopharmacology Bulletin"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291702006736"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.91.2.398"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0597-16"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.186.2.126"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810320088015"},{"key":"e_1_2_6_23_1","volume-title":"The Psychiatric Assessment Schedule for Adults with Developmental Disability (ICD 10 Version).","author":"Moss S.","year":"1996"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.2.1.153"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291796004424"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145702002833"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.12.2057-a"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)00980-X"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.1998.4260455.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.10.e112"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.1.72"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.128.12.1623"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/13651509709024729"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.11.792"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170003779X"},{"key":"e_1_2_6_36_1","volume-title":"International Statistical Classification of Diseases and Related Health Problems, 1989 Revision","author":"World Health Organization","year":"1992"}],"container-title":["Journal of Intellectual Disability Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2788.2006.00895.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2788.2006.00895.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T01:21:17Z","timestamp":1697160077000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2788.2006.00895.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,31]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1365-2788.2006.00895.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2788.2006.00895.x","archive":["Portico"],"relation":{},"ISSN":["0964-2633","1365-2788"],"issn-type":[{"value":"0964-2633","type":"print"},{"value":"1365-2788","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,31]]},"assertion":[{"value":"2006-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}