{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:48:53Z","timestamp":1761929333437},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,5,9]],"date-time":"2007-05-09T00:00:00Z","timestamp":1178668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This is the first published case description in the current literature of the association of definite Gilles de la Tourette syndrome (GTS) and the Smith\u2013Magenis syndrome (SMS), both confirmed by DSM\u2010IV\u2010TR criteria and molecular cytogenetic analysis, respectively. The co\u2010occurrence of GTS, SMS and their common behavioural\/neuropsychiatric abnormalities should warrant further genetic investigation of chromosome 17p11.2 deletion site as it may be a promising region for containing a gene(s) of aetiological importance in the development of the GTS phenotype. Alternatively, the co\u2010occurrence may be due to the common endophenotypic mechanisms shared by these disorders, rather than being specific for GTS that could be explored using strategies of quantitative trait loci \u2013 endophenotype\u2010based approach. Research into this genomic region may also benefit psychiatric genetic research in enhancing understanding of the biological and molecular underpinnings of common behavioural problems that are seen in both GTS and SMS. This would lead to advancement in neurobehavioural\/neuropsychiatric genetics which will help in further explaining the broader perspective of gene\u2013brain\u2013behaviour interrelationships.<\/jats:p>","DOI":"10.1111\/j.1365-2788.2006.00943.x","type":"journal-article","created":{"date-parts":[[2007,5,10]],"date-time":"2007-05-10T08:44:55Z","timestamp":1178786695000},"page":"620-624","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["An individual with Gilles de la Tourette syndrome and Smith\u2013Magenis microdeletion syndrome: is chromosome 17p11.2 a candidate region for Tourette syndrome putative susceptibility genes?"],"prefix":"10.1111","volume":"51","author":[{"given":"B. P.","family":"Shelley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Turk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1116502"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1097-154"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30066"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.9.586"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20631"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30928"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.1998.4260481.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1994.tb11770.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1352\/0895-8017(2001)106<0052:COSIBI>2.0.CO;2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.1994.4.269"},{"key":"e_1_2_6_12_1","first-page":"1207","article-title":"Molecular analysis of the Smith\u2013Magenis syndrome: a possible contiguous\u2010gene syndrome associated with del (17) (p11.2)","volume":"49","author":"Greenberg F.","year":"1991","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-198907000-00015"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(02)00586-X"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.3.425"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-326-7:443"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1234-988X(199612)6:4<203::AID-MPR165>3.3.CO;2-F"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.9.2108"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.17.1.91"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1126"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320240303"},{"key":"e_1_2_6_22_1","first-page":"163","article-title":"Overview of Smith\u2013Magenis syndrome","volume":"31","author":"Smith A. 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