{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:40:06Z","timestamp":1790617206529,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,3,22]],"date-time":"2004-03-22T00:00:00Z","timestamp":1079913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Internal Medicine"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Objectives.\u2002<\/jats:bold> We investigated the prognostic significance of orthostatic hypotension on the risk of myocardial infarction (MI) amongst the elderly.<\/jats:p><jats:p><jats:bold>Design.\u2002<\/jats:bold> Prospective population\u2010based study.\u2002<\/jats:p><jats:p><jats:bold>Setting.\u2002<\/jats:bold> Home\u2010dwelling population.<\/jats:p><jats:p><jats:bold>Subjects.\u2002<\/jats:bold> Orthostatic testing was performed between 8\u2003a.m. and 2\u2003p.m., irrespective of having had meals, on 792 persons, representing 82% of all home\u2010dwelling persons aged \u226570\u2003years living in five municipalities around the city of Oulu.<\/jats:p><jats:p><jats:bold>Main outcome measures.\u2002<\/jats:bold> Occurrence of cases of MI were recorded during mean 3.58 (SD 1.09) years follow\u2010up period, from national mortality statistics and local hospital discharge registers.<\/jats:p><jats:p><jats:bold>Results.\u2002<\/jats:bold> Ninety cases of MI, of which 40 were fatal after initial hospitalization, occurred during the follow\u2010up period. Orthostatic diastolic blood pressure (BP) drop 1\u2003min after standing up was associated with subsequent MI, but systolic BP reactions had no predictive value. According to the Cox regression model, the strongest predictor of the occurrence of subsequent MI was found in regard to \u22658\u2003mmHg drop in diastolic BP 1\u2003min after standing up; adjusted for history of MI, diabetes mellitus, chest pain, use of calcium antagonist, \u03b2\u2010blocker, nitrate and diuretic medication, hazard ratio of MI being 2.00 (1.11\u20133.59).<\/jats:p><jats:p><jats:bold>Conclusions.\u2002<\/jats:bold> Orthostatic testing offers a novel means to assess the risk of MI amongst elderly persons. 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