{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:12:16Z","timestamp":1790233936558,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,10,28]],"date-time":"2005-10-28T00:00:00Z","timestamp":1130457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Internal Medicine"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Objective.\u2002<\/jats:bold> To investigate how variation in the dose of the progestogen influence the impact of 17<jats:italic>\u03b2<\/jats:italic>\u2010oestradiol plus drospirenone (DRSP) treatment on adipose tissue and its secretor function with direct implications for atherogenic metabolites.<\/jats:p><jats:p><jats:bold>Design.\u2002<\/jats:bold> Randomized, double\u2010blind, placebo\u2010controlled trial.<\/jats:p><jats:p><jats:bold>Setting.\u2002<\/jats:bold> Primary care, single study site.<\/jats:p><jats:p><jats:bold>Subjects.\u2002<\/jats:bold> A total of 240 healthy postmenopausal women 53\u201365\u2003years old, 178 completer.<\/jats:p><jats:p><jats:bold>Intervention.\u2002<\/jats:bold> Daily treatment with 1\u2003mg 17<jats:italic>\u03b2<\/jats:italic>\u2010oestradiol plus 1, 2, or 3\u2003mg DRSP, or placebo for 2\u2003years.<\/jats:p><jats:p><jats:bold>Main outcome measures.\u2002<\/jats:bold> Absolute changes in central (CFM) and peripheral fat mass (PFM; dual\u2010energy X\u2010ray absorptiometry, DEXA), adipokines [interleukin (IL)\u20106 and adiponectin], atherogenic metabolites [triglycerides, high\u2010density lipoprotein cholesterol (HDL\u2010C), glucose] and blood pressure.<\/jats:p><jats:p><jats:bold>Results.\u2002<\/jats:bold> Oestradiol plus 1\u2003mg DRSP evoked significant decreases in CFM and the CFM\/PFM ratio from baseline. These benefits virtually decreased with increasing dose of DRSP confounded by dose\u2010dependent increases in CFM and PFM in smokers (<jats:italic>P<\/jats:italic>\u2010value for trends &lt;0.001), in whom the increases in bioavailable oestradiol were half of that in nonsmokers (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Treatment with 3\u2003mg DRSP induced decreases in serum adiponectin by month 6 (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05), which persisted in nonsmokers only and led to significant increases in glucose and triglycerides and decreases in HDL\u2010C (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Adiponectin in smokers normalized by the end of the study parallel with the increases in body fat mass.<\/jats:p><jats:p><jats:bold>Conclusions.\u2002<\/jats:bold> Interactions of the sex steroids with adipose tissue and its secretor function are important determinants of the overall impact of hormone therapy on cardiovascular risk. A DRSP dose up to 2\u2003mg does not seem to exert adverse effects when combined with 1\u2003mg 17<jats:italic>\u03b2<\/jats:italic>\u2010oestradiol.<\/jats:p>","DOI":"10.1111\/j.1365-2796.2005.01571.x","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T13:11:57Z","timestamp":1282137117000},"page":"544-553","source":"Crossref","is-referenced-by-count":31,"title":["Effects of 17<i>\u03b2<\/i>\u2010oestradiol plus different doses of drospirenone on adipose tissue, adiponectin and atherogenic metabolites in postmenopausal women"],"prefix":"10.1111","volume":"258","author":[{"given":"L. B.","family":"TANK\u00d3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"CHRISTIANSEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,14]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90075-6"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-199809120-00004"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.202"},{"key":"e_1_2_8_5_2","first-page":"221","article-title":"Estrogen, progestogens and cardiovascular risk","volume":"44","author":"Stefanick ML","year":"1999","journal-title":"J Reprod Med"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000184246"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01699-5"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(97)00041-8"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57181-7"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56218-9"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.6.1783"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(93)90058-V"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(94)90280-1"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.14.1766"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1479"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-003-0020-2"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.51"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00090-1"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/13697130310001651535"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.GME.0000079740.18541.DB"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198611203152101"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s102380200011"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000144470.55149.E5"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.2.509"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.14.12.8356"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6149"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-35420"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042192-200011000-00005"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1401"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(01)00194-3"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800865"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(03)00181-1"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(01)00255-4"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980201)82:3<553::AID-CNCR18>3.0.CO;2-0"},{"key":"e_1_2_8_35_2","first-page":"65","article-title":"Value of subcutaneous fat in predicting ovulation day","volume":"6","author":"Jamaludin J","year":"1988","journal-title":"Malays J Reprod Health"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00319-1"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802929"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2004.03.002"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-38246"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1480293"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000134955.93951.D5"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2796.2005.01571.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2796.2005.01571.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T15:23:46Z","timestamp":1697124226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2796.2005.01571.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,14]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1111\/j.1365-2796.2005.01571.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2796.2005.01571.x","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,14]]}}}