{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:35:44Z","timestamp":1792719344542,"version":"4.5.0"},"reference-count":75,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,2,23]],"date-time":"2006-02-23T00:00:00Z","timestamp":1140652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Internal Medicine"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p>Blood vessels are permanently subjected to mechanical forces in the form of stretch, encompassing cyclic mechanical strain due to the pulsatile nature of blood flow and shear stress. Significant variations in mechanical forces, of physiological or physiopathological nature, occur <jats:italic>in vivo<\/jats:italic>. These are accompanied by phenotypical modulation of smooth muscle cells and endothelial cells, producing structural modifications of the arterial wall. In all the cases, vascular remodelling can be allotted to a modification of the tensional strain or shear, and underlie a trend to reestablish baseline mechanical conditions. Vascular cells are equipped with numerous receptors that allow them to detect and respond to the mechanical forces generated by pressure and shear stress. The cytoskeleton and other structural components have an established role in mechanotransduction, being able to transmit and modulate tension within the cell via focal adhesion sites, integrins, cellular junctions and the extracellular matrix. Mechanical forces also initiate complex signal transduction cascades, including nuclear factor\u2010<jats:italic>\u03ba<\/jats:italic>B and mitogen\u2010activated protein kinase pathways, leading to functional changes within the cell.<\/jats:p>","DOI":"10.1111\/j.1365-2796.2006.01624.x","type":"journal-article","created":{"date-parts":[[2006,2,23]],"date-time":"2006-02-23T11:15:05Z","timestamp":1140693305000},"page":"381-392","source":"Crossref","is-referenced-by-count":367,"title":["Molecular mechanisms of the vascular responses to haemodynamic forces"],"prefix":"10.1111","volume":"259","author":[{"given":"S.","family":"LEHOUX","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"CASTIER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"TEDGUI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,23]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.16.10.1256"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.3.1042"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118293"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.79.5.1046"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.3.H1354"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.46.30544"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.80.3.320"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026506801659"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000154548.16191.2F"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.79.2.310"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.109.2.853"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.20.13189"},{"issue":"1","key":"e_1_2_8_14_2","doi-asserted-by":"crossref","first-page":"C955","DOI":"10.1152\/ajpcell.1999.277.5.C955","article-title":"RhoA inactivation enhances endothelial barrier function","volume":"277","author":"Carbajal JM","year":"1999","journal-title":"Am J Physiol"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201396"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.32.2.338"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7121"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118442"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.81.6.895"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.11.2366"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.101134098"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119083"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000051860.84509.CE"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/369418a0"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.278.2.H521"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1995.75.3.519"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80222-6"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1794"},{"issue":"1","key":"e_1_2_8_29_2","doi-asserted-by":"crossref","first-page":"C572","DOI":"10.1152\/ajpcell.1997.273.2.C572","article-title":"Differential activation of NF\u2010\u03baB in human aortic endothelial cells conditioned to specific flow environments","volume":"273","author":"Mohan S","year":"1997","journal-title":"Am J Physiol"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00464.2001"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.81.5.797"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.1094"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000086942.13523.88"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni0302-221"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-1738(00)00042-6"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.14.2.261"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1985.248.4.H540"},{"key":"e_1_2_8_38_2","first-page":"H931","article-title":"Adaptations of carotid arteries of young and mature rabbits to reduced carotid blood flow","volume":"256","author":"Langille BL","year":"1989","journal-title":"Am J Physiol"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.12.e120"},{"key":"e_1_2_8_40_2","first-page":"643","article-title":"p47phox\u2010Dependent NADPH oxidase regulates flow\u2010induced vascular remodeling","volume":"111","author":"Castier Y","year":"2005","journal-title":"Circ Res"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.76.2.168"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.41.3.316"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.71.4.932"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00494.2002"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000077044.60138.7C"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000016481.87703.CC"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000115521.95662.7A"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.18.6.922"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/hy09t1.096249"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.5.1236"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.1.569"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.22.2267"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001819"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00220-6"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01811-3"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.21.2035"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(96)01289-6"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000089373.49941.C4"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.4.996"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.82.10.1094"},{"issue":"1","key":"e_1_2_8_61_2","doi-asserted-by":"crossref","first-page":"C1100","DOI":"10.1152\/ajpcell.1999.276.5.C1100","article-title":"Regulation of low shear flow\u2010induced HAEC VCAM\u20101 expression and monocyte adhesion","volume":"276","author":"Mohan S","year":"1999","journal-title":"Am J Physiol"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.16.9052"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901073400103"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1996.00440160064009"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1161\/hq0302.105287"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000125437.28861.40"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.4.845"},{"key":"e_1_2_8_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93287-W"},{"key":"e_1_2_8_69_2","doi-asserted-by":"publisher","DOI":"10.1159\/000159169"},{"key":"e_1_2_8_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(00)00217-7"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.1006\/exmp.1999.2260"},{"key":"e_1_2_8_72_2","doi-asserted-by":"publisher","DOI":"10.1161\/hq0801.093658"},{"key":"e_1_2_8_73_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000116690.17017.8b"},{"key":"e_1_2_8_74_2","doi-asserted-by":"publisher","DOI":"10.1161\/hh0202.103715"},{"key":"e_1_2_8_75_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2001.116668"},{"key":"e_1_2_8_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)03921-8"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2796.2006.01624.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2796.2006.01624.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T21:17:39Z","timestamp":1697145459000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2796.2006.01624.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,23]]},"references-count":75,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1111\/j.1365-2796.2006.01624.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2796.2006.01624.x","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,23]]}}}