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Probands were studied of families with common genetic forms of dyslipidaemia to determine if apo B or apo AI define genetic groups and if apo B or apo AI levels relate to premature coronary artery disease risk. Elevated apo B was characteristic of familial hypercholesterolaemia, familial combined hyperlipidaemia (FCHL), and was seen in individuals with elevated Lp(a). Normal apo B levels were seen in familial hypertriglyceridaemia and in \u2018coronary artery disease with low\u2010HDL cholesterol\u2019. Apo AI levels tended to be low in FCHL and were decreased in \u2018coronary disease with low\u2010HDL cholesterol\u2019. In familial hypertriglyceraemia, even though HDL\u2010C levels were low, normal apo AI and apo B levels were seen in the absence of premature coronary artery disease. Therefore, in genetic dyslipidaemias elevated apo B levels and reduced apo AI levels (or increased apo B\/AI ratio) differ and predict premature coronary artery disease.<\/jats:p>","DOI":"10.1111\/j.1365-2796.2006.01645.x","type":"journal-article","created":{"date-parts":[[2006,4,20]],"date-time":"2006-04-20T13:30:47Z","timestamp":1145539847000},"page":"473-480","source":"Crossref","is-referenced-by-count":27,"title":["Genetics of apolipoprotein B and apolipoprotein AI and premature coronary artery disease"],"prefix":"10.1111","volume":"259","author":[{"given":"A.","family":"ZAMBON","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. G.","family":"BROWN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. S.","family":"DEEB","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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