{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:44:20Z","timestamp":1771263860260,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,4,19]],"date-time":"2006-04-19T00:00:00Z","timestamp":1145404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Internal Medicine"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Objectives.\u2002<\/jats:bold> Patients with bifascicular block (BFB) have a high mortality rate. The purpose of the present study was to identify high\u2010risk patients in a BFB population by performing an extensive cardiac evaluation including noninvasive and invasive tests.<\/jats:p><jats:p><jats:bold>Design.\u2002<\/jats:bold> Population\u2010based study.<\/jats:p><jats:p><jats:bold>Subjects.\u2002<\/jats:bold> A total of 100 patients with BFB, of whom 41 had a history of unexplained syncope, were prospectively studied. The mean age was 68\u2003\u00b1\u200312. All patients were investigated with Holter\u2010monitoring, an exercise test, an echocardiography, and an invasive electrophysiological study. The severity of congestive heart failure (CHF) was assessed by New York Heart Association (NYHA) classification. Patients in NYHA class IV were excluded.<\/jats:p><jats:p><jats:bold>Interventions.\u2002<\/jats:bold> Patients with syncope were recommended prophylactic pacemaker treatment, which was accepted by 31 patients (76%).<\/jats:p><jats:p><jats:bold>Main outcome measures.\u2002<\/jats:bold> All\u2010cause mortality and sudden cardiac death (SCD).<\/jats:p><jats:p><jats:bold>Results.\u2002<\/jats:bold> During a median follow\u2010up of 84\u2003months, 33 patients died, of whom 14 in SCD. In a univariate analysis, high age, a previous myocardial infarction, and CHF were associated with a significantly increased risk of all\u2010cause mortality and SCD. In a Cox multiple regression analysis, CHF was the only independent predictor of all\u2010cause mortality and SCD (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01).<\/jats:p><jats:p><jats:bold>Conclusion.\u2002<\/jats:bold> Patients with BFB have a poor long\u2010term prognosis. The predictive value of noninvasive and invasive investigations is limited. The only independent predictor of all\u2010cause mortality and SCD in this population was the presence of CHF.<\/jats:p>","DOI":"10.1111\/j.1365-2796.2006.01651.x","type":"journal-article","created":{"date-parts":[[2006,4,20]],"date-time":"2006-04-20T10:03:20Z","timestamp":1145527400000},"page":"31-38","source":"Crossref","is-referenced-by-count":12,"title":["Long\u2010term prognosis in patients with bifascicular block \u2013 the predictive value of noninvasive and invasive 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