{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:37:36Z","timestamp":1769146656302,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,9,28]],"date-time":"2006-09-28T00:00:00Z","timestamp":1159401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Internal Medicine"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Background.\u2002<\/jats:bold> Implantable cardioverter defibrillators (ICDs) are a life\u2010saving therapy for many patients with cardiovascular disease at increased risk of fatal dysrhythmias. As men comprise the majority of the study population (67\u201392%) in clinical trials, the benefit to women is unknown. We performed a meta\u2010analysis of primary prevention trials to evaluate the impact of ICDs in men and women on death from any cause.<\/jats:p><jats:p><jats:bold>Methods.\u2002<\/jats:bold> Included trials met the following criteria: (i) randomized controlled trials versus standard of care, (ii) ICD used as primary prevention in a well\u2010described protocol and (iii) data provided on risk of death from any cause for both male and female patients.<\/jats:p><jats:p><jats:bold>Results.\u2002<\/jats:bold> Five clinical trials were included in this meta\u2010analysis. The risk of death from any cause was significantly reduced by 26% in male patients who received ICD therapy compared to control, hazard ratio (HR) 0.74 (95% CI 0.60\u20130.91) but not amongst female patients, HR 0.81 (95% CI 0.60\u20131.09). As the COMPANION trial evaluated the combination of biventricular pacemaker with ICD therapy we conducted a separate analysis without the inclusion of this study. Male patients receiving ICD therapy demonstrated a similar 24% reduction in risk of death from any cause, HR 0.76 (95% CI 0.58\u20130.99) whilst female patients demonstrated a reduction of only 12%, HR 0.88 (95% CI 0.63\u20131.22).<\/jats:p><jats:p><jats:bold>Conclusions.\u2002<\/jats:bold> Unlike their male counterparts, females did not significantly benefit from ICD therapy and without concurrent biventricular pacing, appear only to achieve a nonsignificant 12% reduction in risk of death.<\/jats:p>","DOI":"10.1111\/j.1365-2796.2006.01713.x","type":"journal-article","created":{"date-parts":[[2006,9,28]],"date-time":"2006-09-28T09:32:33Z","timestamp":1159435953000},"page":"467-473","source":"Crossref","is-referenced-by-count":24,"title":["The impact of gender on survival amongst patients with implantable cardioverter defibrillators for primary prevention against sudden cardiac death"],"prefix":"10.1111","volume":"260","author":[{"given":"N. N.","family":"HENYAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"WHITE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. L.","family":"GILLESPIE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"SMITH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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