{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:34:33Z","timestamp":1790861673522,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T00:00:00Z","timestamp":1163635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Internal Medicine"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Objective.\u2002<\/jats:bold> To analyse the mid region of plasma N\u2010terminal pro\u2010atrial natriuretic peptide (MR\u2010proANP) levels in patients with lower respiratory tract infections to evaluate its prognostic use for the severity of disease and outcome.<\/jats:p><jats:p><jats:bold>Design.\u2002<\/jats:bold> Prospective observational study.<\/jats:p><jats:p><jats:bold>Setting.\u2002<\/jats:bold> Emergency department of a university hospital.<\/jats:p><jats:p><jats:bold>Subjects.\u2002<\/jats:bold> A total of 545 consecutive patients with lower respiratory tract infections and 50 healthy controls.<\/jats:p><jats:p><jats:bold>Interventions.\u2002<\/jats:bold> MR\u2010proANP was measured in serum from all patients using a new sandwich immunoassay.<\/jats:p><jats:p><jats:bold>Results.\u2002<\/jats:bold> MR\u2010proANP levels (median [IQR], in pmol\u2003L<jats:sup>\u22121<\/jats:sup>) were significantly higher in patients with lower respiratory tract infections when compared with controls (138.0 [74.1\u2013279.0] vs. 72.7 [62.5\u201389.5], <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001), with highest levels in patients with community\u2010acquired pneumonia (CAP). MR\u2010proANP, but not C\u2010reactive protein (CRP) levels, gradually increased with increasing severity of CAP, classified according to the pneumonia severity index (PSI) score (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). On admission, MR\u2010proANP levels were significantly higher in nonsurvivors when compared with survivors (293.0 [154.0\u2013633.0] vs. 129.0 [71.4\u2013255.0], <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). In a receiver operating characteristic (ROC) analysis for the prediction of survival of patients with CAP the area under the ROC curve (AUC) for MR\u2010proANP was 0.69, similar when compared with the PSI (AUC 0.74, <jats:italic>P<\/jats:italic>\u2003=\u20030.31), and better when compared with other biomarkers, i.e. procalcitonin (AUC 0.57, <jats:italic>P<\/jats:italic>\u2003=\u20030.08), CRP (AUC 0.52, <jats:italic>P<\/jats:italic>\u2003=\u20030.02), and leucocyte count (AUC 0.56, <jats:italic>P<\/jats:italic>\u2003=\u20030.07).<\/jats:p><jats:p><jats:bold>Conclusions.\u2002<\/jats:bold> MR\u2010proANP levels are increased in lower respiratory tract infections, especially in CAP. Together with other clinical, radiographic and laboratory findings, MR\u2010proANP levels might be helpful for the risk stratification in CAP.<\/jats:p>","DOI":"10.1111\/j.1365-2796.2006.01722.x","type":"journal-article","created":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T13:58:28Z","timestamp":1163685508000},"page":"568-576","source":"Crossref","is-referenced-by-count":46,"title":["Circulating levels of pro\u2010atrial natriuretic peptide in lower respiratory tract infections"],"prefix":"10.1111","volume":"260","author":[{"given":"B.","family":"M\u00dcLLER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"S\u00dcESS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"SCHUETZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"M\u00dcLLER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"BINGISSER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"BERGMANN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"STOLZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"TAMM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. G.","family":"MORGENTHALER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"CHRIST\u2010CRAIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,16]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20233"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/15216540212336"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc3015"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.021204"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.9.1059"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.at1010"},{"key":"e_1_2_7_8_2","first-page":"R567","article-title":"Immunoreactive atrial natriuretic factor is increased in ovine model of endotoxemia","volume":"254","author":"Lubbesmeyer HJ","year":"1988","journal-title":"Am J Physiol"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199511000-00017"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)03034-1"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0006"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)06031-5"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15591-8"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200512-1922OC"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701233360402"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14416-9"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-106-2-196"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-12-200012190-00014"},{"key":"e_1_2_7_19_2","article-title":"Expert panel report 2. Guidelines for the diagnosis and management of asthma","author":"National Institutes of Health, National Heart, Lung, and Blood Institute","journal-title":"NIH publication 1997 no. 97-4051"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.3.2009052"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(05)70387-4"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-6-428"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90177-Q"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100960000413"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/jamia.2000.0070055"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.5.377"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.4.1335"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000075208"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90069-A"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.4.2223"},{"key":"e_1_2_7_31_2","first-page":"451","article-title":"Procalcitonin in bacterial infections \u2013 hype, hope, more or less","volume":"135","author":"Christ\u2010Crain M","year":"2005","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.4.1087"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2005.01540.x"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031681"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343878"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200101000-00019"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200109000-00029"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1910-0"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc2890"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.4.1330"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07424-7"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000129305.25115.80"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1990.258.2.E243"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.110.2.462"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08020216"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.032490"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000094225.18237.20"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000092454.55342.1A"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2796.2006.01722.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2796.2006.01722.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T16:12:51Z","timestamp":1697386371000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2796.2006.01722.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,16]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1365-2796.2006.01722.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2796.2006.01722.x","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,16]]}}}