{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:31:35Z","timestamp":1791297095942,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T00:00:00Z","timestamp":1321920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Internal Medicine"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:bold>Abstract.\u2002<\/jats:bold> Tseng HF, Liu A, Sy L, Marcy SM, Fireman B, Weintraub E, Baggs J, Weinmann S, Baxter R, Nordin J, Daley MF, Jackson L, Jacobsen SJ, for the Vaccine Safety Datalink (VSD) Team (Kaiser Permanente, Pasadena, CA; Kaiser Permanente, Oakland, CA; Centers for Disease Control and Prevention, Atlanta, GA; Kaiser Permanente, Portland, OR; HealthPartners Research Foundation, Minneapolis, MN; Kaiser Permanente, Denver, CO; and Group Health Cooperative of Puget Sound, Seattle, WA; USA). Safety of zoster vaccine in adults from a large managed\u2010care cohort: a Vaccine Safety Datalink study. <jats:italic>J Intern Med<\/jats:italic> 2012; <jats:bold>271<\/jats:bold>: 510\u2013520.<\/jats:p><jats:p><jats:bold>Objectives.\u2002<\/jats:bold> The aim of this study was to examine a large cohort of adults who received the zoster vaccine for evidence of an increased risk of prespecified adverse events requiring medical attention.<\/jats:p><jats:p><jats:bold>Design.\u2002<\/jats:bold> Two self\u2010comparison approaches, including a case\u2010centred approach and a self\u2010controlled case series (SCCS) analysis were used.<\/jats:p><jats:p><jats:bold>Setting.\u2002<\/jats:bold> Eight managed\u2010care organizations participating in the Vaccine Safety Datalink project in the United States.<\/jats:p><jats:p><jats:bold>Subjects.\u2002<\/jats:bold> A total of 193\u2003083 adults aged 50 and older receiving a zoster vaccine from 1 January 2007 to 31 December 2008 were included.<\/jats:p><jats:p><jats:bold>Main outcome measures.\u2002<\/jats:bold> Prespecified adverse events were identified by aggregated <jats:italic>International Classification of Diseases, Ninth Revision<\/jats:italic> (ICD\u20109) codes in automated health plan datasets.<\/jats:p><jats:p><jats:bold>Results.\u2002<\/jats:bold> The risk of allergic reaction was significantly increased within 1\u20137\u2003days of vaccination [relative risk\u2003=\u20032.13, 95% confidence interval (CI): 1.87\u20132.40 by case\u2010centred method and relative rate\u2003=\u20032.32, 95% CI: 1.85\u20132.91 by SCCS]. No increased risk was found for the following adverse event groupings: cerebrovascular events; cardiovascular events; meningitis; encephalitis; and encephalopathy; and Ramsay\u2010Hunt syndrome and Bell\u2019s palsy.<\/jats:p><jats:p><jats:bold>Conclusions.\u2002<\/jats:bold> The results of this study support the findings from the prelicensure clinical trials, providing reassurance that the zoster vaccine is generally safe and well\u2010tolerated with a small increased risk of allergic reactions in 1\u20137\u2003days after vaccination.<\/jats:p>","DOI":"10.1111\/j.1365-2796.2011.02474.x","type":"journal-article","created":{"date-parts":[[2011,10,25]],"date-time":"2011-10-25T16:26:03Z","timestamp":1319559963000},"page":"510-520","source":"Crossref","is-referenced-by-count":62,"title":["Safety of zoster vaccine in adults from a large managed\u2010care cohort: a Vaccine Safety Datalink study"],"prefix":"10.1111","volume":"271","author":[{"given":"H. F.","family":"Tseng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Sy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Marcy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Fireman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Weintraub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Baggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Weinmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Baxter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Nordin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. F.","family":"Daley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J.","family":"Jacobsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Vaccine Safety Datalink (VSD) Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,22]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-9-201005040-00011"},{"key":"e_1_2_8_3_2","first-page":"1","article-title":"Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"57","author":"Harpaz R","year":"2008","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051016"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-9-201005040-00004"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.6.765"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00132-2"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500410"},{"key":"e_1_2_8_9_2","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1128\/JCM.38.7.2753-2755.2000","article-title":"Detection of human herpesvirus 6 and varicella\u2010zoster virus in tear fluid of patients with Bell\u2019s palsy by PCR","volume":"38","author":"Pitkaranta A","year":"2000","journal-title":"J Clin Microbiol"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003023420906"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/13550280290167902"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.5858\/2001-125-0770-VZVIOT"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2384"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.06.038"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000234067.84848.e1"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp173"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0665"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.08.088"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.2307\/2533328"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2477"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1086\/528696"},{"key":"e_1_2_8_22_2","first-page":"201","article-title":"Smallpox vaccine adverse events among civilians \u2013 United States, March 4\u201310, 2003","volume":"52","author":"Centers for Disease Control and Prevention","year":"2003","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70140-9"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/649568"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2010.10.012"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2796.2011.02474.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2796.2011.02474.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T20:11:12Z","timestamp":1698696672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2796.2011.02474.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,22]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1365-2796.2011.02474.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2796.2011.02474.x","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,22]]}}}