{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:30:22Z","timestamp":1787729422783,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,11,30]],"date-time":"2011-11-30T00:00:00Z","timestamp":1322611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Internal Medicine"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p><jats:bold>Abstract.\u2002<\/jats:bold> Bodegard J, Skretteberg PT, Gjesdal K, Py\u00f6r\u00e4l\u00e4 K, Kjeldsen SE, Liest\u00f8l K, Erikssen G, Erikssen J (Oslo University Hospital, Oslo; University of Oslo, Oslo; University of Eastern Finland, Kuopio; University of Oslo, Oslo; Oslo University Hospital, Oslo). Low\u2010grade systolic murmurs in healthy middle\u2010aged individuals: innocent or clinically significant? A 35\u2010year follow\u2010up study of 2014 Norwegian men. <jats:italic>J Intern Med<\/jats:italic> 2012; <jats:bold>271<\/jats:bold>: 581\u2013588.<\/jats:p><jats:p><jats:bold>Objective.\u2002<\/jats:bold> To determine whether a low\u2010grade systolic murmur, found at heart auscultation, in middle\u2010aged healthy men influences the long\u2010term risk of aortic valve replacement (AVR) and death from cardiovascular disease (CVD).<\/jats:p><jats:p><jats:bold>Setting and subjects.\u2002<\/jats:bold> During 1972\u20131975, 2014 apparently healthy men aged 40\u201359\u2003years underwent an examination programme including case history, clinical examination, blood tests and a symptom\u2010limited exercise ECG test. Heart auscultation was performed under standardized conditions, and murmurs were graded on a scale from I to VI. No men were found to have grade V\/VI murmurs. Participants were followed for up to 35\u2003years.<\/jats:p><jats:p><jats:bold>Results.\u2002<\/jats:bold> A total of 1541 men had no systolic murmur; 441 had low\u2010grade murmurs (grade I\/II) and 32 had moderate\u2010grade murmurs (grade III\/IV). Men with low\u2010grade murmurs had a 4.7\u2010fold [95% confidence interval (CI) 2.1\u201311.1] increased age\u2010adjusted risk of AVR, but no increase in risk of CVD death. Men with moderate\u2010grade murmurs had an 89.3\u2010fold (95% CI 39.2\u2013211.2) age\u2010adjusted risk of AVR and a 1.5\u2010fold (95% CI 0.8\u20132.5) age\u2010adjusted increased risk of CVD death.<\/jats:p><jats:p><jats:bold>Conclusions.\u2002<\/jats:bold> Low\u2010grade systolic murmur was detected at heart auscultation in 21.9% of apparently healthy middle\u2010aged men. Men with low\u2010grade murmur had an increased risk of AVR, but no increase in risk of CVD death. Only 1.6% of men had moderate\u2010grade murmur; these men had a very high risk of AVR and a 1.5\u2010fold albeit non\u2010significant increase in risk of CVD death.<\/jats:p>","DOI":"10.1111\/j.1365-2796.2011.02480.x","type":"journal-article","created":{"date-parts":[[2011,11,7]],"date-time":"2011-11-07T15:26:34Z","timestamp":1320679594000},"page":"581-588","source":"Crossref","is-referenced-by-count":11,"title":["Low\u2010grade systolic murmurs in healthy middle\u2010aged individuals: innocent or clinically significant? A 35\u2010year follow\u2010up study of 2014 Norwegian men"],"prefix":"10.1111","volume":"271","author":[{"given":"J.","family":"Bodegard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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