{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:06:35Z","timestamp":1791173195623,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,4]],"date-time":"2012-01-04T00:00:00Z","timestamp":1325635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Internal Medicine"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p><jats:bold>Abstract.\u2002<\/jats:bold> Trumpfheller C, Longhi MP, Caskey M, Idoyaga J, Bozzacco L, Keler T, Schlesinger SJ, Steinman RM (The Rockefeller University, New York, NY; and Celldex Therapeutics, Phillipsburg, NJ; USA). Dendritic cell\u2010targeted protein vaccines: a novel approach to induce T\u2010cell immunity (Review). <jats:italic>J Intern Med<\/jats:italic> 2012; <jats:bold>271<\/jats:bold>: 183\u2013192.<\/jats:p><jats:p>Current vaccines primarily work by inducing protective antibodies. However, in many infections like HIV, malaria and tuberculosis as well as cancers, there remains a need for durable and protective T\u2010cell immunity. Here, we summarize our efforts to develop a safe T\u2010cell\u2013based protein vaccine that exploits the pivotal role of dendritic cells (DC) in initiating adaptive immunity. Focusing on HIV, gag\u2010p24 protein antigen is introduced into a monoclonal antibody (mAb) that efficiently and specifically targets the DEC\u2010205 antigen uptake receptor on DC. When administered together with synthetic double\u2010stranded RNA, polyriboinosinic:polyribocytidylic acid (poly IC) or its analogue poly IC stabilized with carboxymethylcellulose and poly\u2010L\u2010lysine (poly ICLC), as adjuvant, HIV gag\u2010p24 within anti\u2010DEC\u2010205 mAb is highly immunogenic in mice, rhesus macaques, and in ongoing research, healthy human volunteers. Human subjects form both T\u2010 and B\u2010cell responses to DC\u2010targeted protein. Thus, DC\u2010targeted protein vaccines are a potential new vaccine platform, either alone or in combination with highly attenuated viral vectors, to induce integrated immune responses against microbial or cancer antigens, with improved ease of manufacturing and clinical use.<\/jats:p>","DOI":"10.1111\/j.1365-2796.2011.02496.x","type":"journal-article","created":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T07:51:20Z","timestamp":1322725880000},"page":"183-192","source":"Crossref","is-referenced-by-count":145,"title":["Dendritic cell\u2010targeted protein vaccines: a novel approach to induce T\u2010cell immunity"],"prefix":"10.1111","volume":"271","author":[{"given":"C.","family":"Trumpfheller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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