{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:31:15Z","timestamp":1776702675595,"version":"3.51.2"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T00:00:00Z","timestamp":1328140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Internal Medicine"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p><jats:bold>Abstract.\u2002<\/jats:bold> Pirro M, Bocci EB, Di Filippo F, Schillaci G, Mannarino MR, Bagaglia F, Gerli R, Mannarino E (From the Unit of Internal Medicine, Angiology and Arteriosclerosis, Department of Clinical and Experimental Medicine; Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy). Imbalance between endothelial injury and repair in patients with polymyalgia rheumatica: improvement with corticosteroid treatment. <jats:italic>J Intern Med<\/jats:italic> 2012; <jats:bold>272<\/jats:bold>: 177\u2013184.<\/jats:p><jats:p><jats:bold>Objectives.\u2002<\/jats:bold> Polymyalgia rheumatica (PMR) is a rheumatic disease that is characterized by intense activation of systemic inflammation. Systemic inflammation has been associated with an imbalance between endothelial injury and repair, defined by an increased number of circulating endothelial microparticles (EMPs) and a reduced number of endothelial progenitor cells (EPCs). We investigated the association between inflammation and endothelial injury and repair in patients with PMR and evaluated the effects of corticosteroid therapy on EMP and EPC levels.<\/jats:p><jats:p><jats:bold>Design, setting and subjects.\u2002<\/jats:bold> We conducted a case\u2013control study in 34 patients with never\u2010treated active PMR and 34 healthy age\u2010 and sex\u2010matched controls. Patients with PMR participated in a 1\u2010month intervention open\u2010label study with corticosteroid therapy. Circulating EMPs (CD31+\/CD42\u2212) and EPCs (CD34+\/KDR+) were quantified by fluorescence\u2010activated cell sorting analysis.<\/jats:p><jats:p><jats:bold>Results.\u2002<\/jats:bold> Patients with PMR had an increased EMP\/EPC ratio compared with controls [median (IQR): 6.5 (3.0\u201311.5) vs. 1.1 (0.7\u20131.5), <jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001], because of both increased EMP and reduced EPC levels. Levels of C\u2010reactive protein (CRP) were associated with an increased EMP\/EPC ratio (\u03b2\u2003=\u20030.48, <jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.001), irrespective of traditional cardiovascular risk factors. Corticosteroid therapy led to a significant CRP reduction [from 3.9 (1.5\u20136.7) to 0.6 (0.2\u20131.2) mg\u2003dL<jats:sup>\u22121<\/jats:sup>, <jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05], paralleled by a consistent 81% decline in the EMP\/EPC ratio. CRP and EMP\/EPC ratio reductions were significantly correlated (rho\u2003=\u20030.37, <jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.04).<\/jats:p><jats:p><jats:bold>Conclusions.\u2002<\/jats:bold> Polymyalgia rheumatica is associated with a significant imbalance between endothelial injury and repair, which is dependent on the degree of systemic inflammation. Attenuation of inflammation by short\u2010term corticosteroid therapy might have a role in limiting endothelial fragmentation and promote endothelial repair.<\/jats:p>","DOI":"10.1111\/j.1365-2796.2011.02510.x","type":"journal-article","created":{"date-parts":[[2011,12,30]],"date-time":"2011-12-30T09:40:33Z","timestamp":1325238033000},"page":"177-184","source":"Crossref","is-referenced-by-count":25,"title":["Imbalance between endothelial injury and repair in patients with polymyalgia rheumatica: improvement with corticosteroid treatment"],"prefix":"10.1111","volume":"272","author":[{"given":"M.","family":"Pirro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. B.","family":"Bocci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Di Filippo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Schillaci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Mannarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Bagaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Gerli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Mannarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra011913"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24793"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.009"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.02.009"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.20.2474"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2010.12.040"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.12.006"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20878"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20322"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.507996"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2664"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21311"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/34.3.261"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0003319708320761"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000243941.72375.15"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00639.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.218123"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022287"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043814"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.119495"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq041"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.81"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep303a"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39514.653588.80"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.07.006"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22548"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-5-672"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(03)00103-0"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/1074248408331021"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.01.063"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.05.034"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.04.003"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4985"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000127577.63323.24"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-02-0111"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656561003724739"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0455"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22418"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.13.6.892"},{"key":"e_1_2_7_41_2","first-page":"74","article-title":"Steroid therapy improves endothelial function in patients with biopsy\u2010proven giant cell arteritis","volume":"33","author":"Gonzalez\u2010Juanatey C","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2004.01345.x"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.07.012"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq478"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.504340"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011477"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2796.2011.02510.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2796.2011.02510.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T20:14:15Z","timestamp":1697314455000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2796.2011.02510.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,2]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1111\/j.1365-2796.2011.02510.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2796.2011.02510.x","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,2]]}}}