{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:51:51Z","timestamp":1788540711784,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T00:00:00Z","timestamp":1334793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Internal Medicine"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p><jats:bold>Abstract.\u2002<\/jats:bold> Tripodi A, Palareti G (IRCCS C\u00e0 Granda Maggiore Hospital Foundation and Universit\u00e0 degli Studi di Milano, Milano, Italy; S.Orsola\u2010Malpighi University Hospital, Bologna, Italy). New anticoagulant drugs for treatment of venous thromboembolism and stroke prevention in atrial fibrillation (Review). <jats:italic>J Intern Med<\/jats:italic> 2012; <jats:bold>271<\/jats:bold>: 554\u2013565.<\/jats:p><jats:p>Venous thromboembolism (including deep vein thrombosis and pulmonary embolism) and atrial fibrillation are common conditions in Western countries. The mainstay of treatment and prevention for these diseases is fast\u2010acting anticoagulant drugs such as heparins and vitamin K antagonists. The use of these drugs is, however, complex and demanding for both patients and physicians. Recently, new antithrombotic drugs that act directly by inhibiting activated coagulation factors such as factor X or thrombin have been developed and investigated in phase III clinical trials. The aim of this article is to review: (i) the need to develop new drugs; (ii) their efficacy\/safety as demonstrated in clinical trials; (iii) the need for laboratory monitoring and (iv) the direction towards the use of these new drugs in the real\u2010life clinical situation.<\/jats:p>","DOI":"10.1111\/j.1365-2796.2012.02541.x","type":"journal-article","created":{"date-parts":[[2012,3,24]],"date-time":"2012-03-24T12:42:51Z","timestamp":1332592971000},"page":"554-565","source":"Crossref","is-referenced-by-count":24,"title":["New anticoagulant drugs for treatment of venous thromboembolism and stroke prevention in atrial 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