{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:39:22Z","timestamp":1767962362195,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,8,5]],"date-time":"2012-08-05T00:00:00Z","timestamp":1344124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Primary hyperparathyroidism (<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>) has been associated with low\u2010grade inflammation and elevated risk of cardiovascular disease (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>). In inflammatory conditions, interferon\u2010\u03b3 (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3) activity is enhanced and a decreased circulating concentration of vitamin B6 is often observed. Such changes in <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 activity or vitamin B6 levels have been associated with increased incidence of <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>. The aim of the study was to investigate systemic markers of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3\u2010mediated immune activation, such as neopterin, the kynurenine\u2010to\u2010tryptophan ratio (<jats:styled-content style=\"fixed-case\">KTR<\/jats:styled-content>) and kynurenine pathway metabolites, as well as <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>6 vitamers in patients with <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design\/subjects<\/jats:title><jats:p>A total of 57 patients with <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> and a control group of 20 healthy blood donors were included in this study. <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> patients who responded positively to parathyroidectomy were followed for 6\u00a0months. Forty\u2010three patients participated in the longitudinal study in which blood samples were taken at inclusion and 1, 3 and 6\u00a0months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma concentrations of the B6 vitamers pyridoxal 5\u2032\u2010phosphate (<jats:styled-content style=\"fixed-case\">PLP<\/jats:styled-content>) (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.007) and pyridoxal (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.013) were significantly lower in the patient group compared to healthy control subjects. An increase in the <jats:styled-content style=\"fixed-case\">KTR<\/jats:styled-content> indicated that the kynurenine pathway of tryptophan metabolism was altered in <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> patients (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.015). During the initial 6\u00a0months after surgery, levels of <jats:styled-content style=\"fixed-case\">PLP<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and anthranilic acid (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) increased significantly, whereas neopterin decreased (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.018).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study demonstrate altered levels of vitamin B6 and the <jats:styled-content style=\"fixed-case\">KTR<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> patients, both of which may reflect cellular immune activation. These abnormalities should be considered in relation to the increased risk of <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> previously observed in patients with <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2796.2012.02570.x","type":"journal-article","created":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T13:45:28Z","timestamp":1365774328000},"page":"583-591","source":"Crossref","is-referenced-by-count":14,"title":["Vitamin <scp>B<\/scp>6 status and interferon\u2010\u03b3\u2010mediated immune activation in primary hyperparathyroidism"],"prefix":"10.1111","volume":"272","author":[{"given":"M. H. E.","family":"Christensen","sequence":"first","affiliation":[{"name":"Institute of Medicine, University of Bergen Bergen Norway"},{"name":"Hormone Laboratory, Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. K. R.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Institute of Medicine, University of Bergen Bergen Norway"},{"name":"Department of Heart Disease Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Nordb\u00f8","sequence":"additional","affiliation":[{"name":"Department of Surgery Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"Varhaug","sequence":"additional","affiliation":[{"name":"Department of Surgery Haukeland University Hospital Bergen Norway"},{"name":"Institute of Surgical Science, University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d8.","family":"Midttun","sequence":"additional","affiliation":[{"name":"Bevital A\/S Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"Ueland","sequence":"additional","affiliation":[{"name":"Institute of Medicine, University of Bergen Bergen Norway"},{"name":"Laboratory of Clinical Biochemistry, Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. K.","family":"Nyg\u00e5rd","sequence":"additional","affiliation":[{"name":"Institute of Medicine, University of Bergen Bergen Norway"},{"name":"Department of Heart Disease Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Mellgren","sequence":"additional","affiliation":[{"name":"Institute of Medicine, University of Bergen Bergen Norway"},{"name":"Hormone Laboratory, Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. A.","family":"Lien","sequence":"additional","affiliation":[{"name":"Institute of Medicine, University of Bergen Bergen Norway"},{"name":"Hormone Laboratory, Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02371.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02363.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0238"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e3282f2838f"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1836"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2742"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.808733"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1096\/fj.04-2645fje","article-title":"IKKbeta\u2010dependent NF\u2010kappaB pathway controls vascular inflammation and intimal hyperplasia","volume":"19","author":"Bu DX","year":"2005","journal-title":"FASEB J"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1164"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.219329"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2005.06.013"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.160.1.310"},{"key":"e_1_2_7_14_1","first-page":"491","article-title":"Relationship between body store of vitamin B6 and plasma pyridoxal\u2010P clearance: metabolic balance studies in humans","volume":"106","author":"Lui A","year":"1985","journal-title":"J Lab Clin Med"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2007.12.003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1839"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28571"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020481"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.4013"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1093\/clinchem\/33.11.2028","article-title":"Simultaneous determination of neopterin and creatinine in serum with solid\u2010phase extraction and on\u2010line elution liquid chromatography","volume":"33","author":"Werner ER","year":"1987","journal-title":"Clin Chem"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1093\/clinchem\/35.12.2305","article-title":"Urinary neopterin concentrations vs total neopterins for clinical utility","volume":"35","author":"Fuchs D","year":"1989","journal-title":"Clin Chem"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.44.7.592"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(97)81007-5"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1373\/49.2.286"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5893.643"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.077180"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511754098"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2007.04.010"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(91)90005-U"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2010.543694"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650081003"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013657"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110340"},{"key":"e_1_2_7_34_1","first-page":"1","article-title":"Vitamin B6: a challenging link between nutrition and inflammation in CVD","volume":"13","author":"Lotto V","year":"2011","journal-title":"Br J Nutr"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.029751"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.11.3308"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4831-6750-3.50009-3"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.133082"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(97)00078-1"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.5.1901"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-004-0528-9"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2010.509811"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000294405"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.03.025"},{"key":"e_1_2_7_45_1","first-page":"278","article-title":"Vitamin B6","volume":"63","author":"Bitsch R","year":"1993","journal-title":"Int J Vitam Nutr Res"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.04.070184.002323"},{"issue":"3","key":"e_1_2_7_47_1","first-page":"S39","article-title":"Dietary and other determinants of vitamin B6 parameters","volume":"51","author":"Brussaard JH","year":"1997","journal-title":"Eur J Clin Nutr"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/36.1.143"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2796.2012.02570.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2796.2012.02570.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T07:47:21Z","timestamp":1698652041000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2796.2012.02570.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,5]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/j.1365-2796.2012.02570.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2796.2012.02570.x","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,5]]}}}