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Objects of interest such as neurones, glial cells, blood vessels or pathological features such as protein deposits appear as sectional profiles in a two\u2010dimensional section. These objects may not be randomly distributed within the section but exhibit a spatial pattern, a departure from randomness either towards regularity or clustering. The methods described include simple tests of whether the planar distribution of a histological feature departs significantly from randomness using randomized points, lines or sample fields and more complex methods that employ grids or transects of contiguous fields, and which can detect the intensity of aggregation and the sizes, distribution and spacing of clusters. The usefulness of these methods in understanding the pathogenesis of neurodegenerative diseases such as Alzheimer's disease and Creutzfeldt\u2010Jakob disease is discussed.<\/jats:p>","DOI":"10.1111\/j.1365-2818.2006.01559.x","type":"journal-article","created":{"date-parts":[[2006,3,21]],"date-time":"2006-03-21T14:51:27Z","timestamp":1142952687000},"page":"153-158","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Methods of studying the planar distribution of objects in histological sections of brain tissue"],"prefix":"10.1111","volume":"221","author":[{"given":"R. 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