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Given that D<jats:sub>1<\/jats:sub> activation leads to increases in cyclic AMP (cAMP), we hypothesised that, in the VTA, progesterone's actions on lordosis that involve D<jats:sub>1<\/jats:sub> are mediated, in part, by cAMP. In Experiment 1, naturally receptive rats and hamsters were pretested for lordosis, infused with the cAMP analogue 8\u2010bromo\u2010cAMP (200\u2003ng) or vehicle to the VTA, and tested again 30\u2003min later. In Experiments 2 and 3, ovariectomised, oestradiol (10\u2003\u00b5g)\u2003+\u2003progesterone (0 or 100\u2003\u00b5g)\u2010primed rats and oestradiol (10\u2003\u00b5g)\u2003+\u2003progesterone (0 or 200\u2003\u00b5g)\u2010primed hamsters were pretested for lordosis and infused with 8\u2010bromo\u2010cAMP (200\u2003ng), the adenylyl cyclase inhibitor 2\u2032,5\u2032\u2010dideoxyadenosine (12\u2003\u00b5<jats:sc>M<\/jats:sc>) or vehicle to the VTA. Subjects were tested again 30\u2003min later. In Experiment 4, oestradiol\u2003+\u2003progesterone\u2010primed rats and hamsters were pretested and infused with the D<jats:sub>1<\/jats:sub> agonist SKF38393 (0 or 100\u2003ng) to the VTA. Thirty minutes later, subjects were tested again and infused with 2\u2032,5\u2032\u2010dideoxyadenosine (12\u2003\u00b5<jats:sc>M<\/jats:sc>) or vehicle. Subjects were tested again 30\u2003min later. VTA infusions of 8\u2010bromo\u2010cAMP enhanced lordosis of naturally receptive or hormone\u2010primed rats and hamsters and 2\u2032,5\u2032\u2010dideoxyadenosine decreased lordosis of oestradiol\u2003+\u2003progesterone\u2010primed rats and hamsters. D<jats:sub>1<\/jats:sub>\u2010mediated increases in progesterone\u2010facilitated lordosis were reduced by 2\u2032,5\u2032\u2010dideoxyadenosine. These data suggest that progesterone\u2010facilitated lordosis of rats and hamsters may be modulated by D<jats:sub>1<\/jats:sub> and cAMP activity in the VTA.<\/jats:p>","DOI":"10.1111\/j.1365-2826.2006.01488.x","type":"journal-article","created":{"date-parts":[[2006,9,4]],"date-time":"2006-09-04T14:57:46Z","timestamp":1157381866000},"page":"902-914","source":"Crossref","is-referenced-by-count":15,"title":["In the Ventral Tegmental Area, Cyclic AMP Mediates the Actions of Progesterone at Dopamine Type 1 Receptors for Lordosis of Rats and Hamsters"],"prefix":"10.1111","volume":"18","author":[{"given":"S. M.","family":"Petralia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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