{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T05:50:16Z","timestamp":1697176216924},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T00:00:00Z","timestamp":1165363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>Central administration of angiotensin (Ang) II stimulates thirst and sodium intake via the AT\u20101 receptor. Mineralocorticoid pretreatment enhances Ang II\u2010induced drinking of hypertonic salt solutions (i.e. the synergy theory) in Wistar and Sprague\u2010Dawley rats. Electrophysiological experiments using iontophoretic application of Ang II, and the AT\u20101 receptor specific nonpeptide antagonist losartan, have shown excitation of neurones in the preoptic\/medial septum region of urethane anaesthetised male Wistar rats. Deoxycorticosterone acetate (DOCA) pretreatment further enhanced this neuronal excitation to Ang II and reduced the responses to losartan. This generated the hypothesis that DOCA\u2010enhanced Ang II\u2010induced neuronal excitation was necessary for the enhanced salt intake of synergy theory. We tested this hypothesis in Fischer 344 rats that are known to have a low basal salt appetite and reduced sensitivity for i.c.v. Ang II. We compared the effect of DOCA pretreatment on i.c.v. Ang II\u2010induced water and 2% NaCl intake in behaving adult male, Fischer rats, as well as preoptic\/medial septum region neuronal responses to Ang II and losartan, using a seven\u2010barrelled micro\u2010iontophoretic electrode sealed to a recording electrode in urethane anaesthetised, male Fischer rats. Two groups were used: one pretreated with DOCA (0.5\u2003mg\/day for 3\u2003days) and the other comprising controls, treated with isotonic saline. Ang II applied iontophoretically increased activity in 31% of the spontaneously active neurones. Following DOCA pretreatment, the responsiveness to Ang II (when applied after aldosterone) was increased. By contrast, in the behaving animals, water and 2% NaCl intake in response to i.c.v. Ang II were not enhanced by DOCA pretreatment. These results do not support the working hypothesis but could be interpreted as evidence for the existence of two separately modulated central Ang II systems: one responding to mineralocorticoids with increased neuronal activity and the other responsible for the Ang II\u2010induced sodium appetite in conscious rats.<\/jats:p>","DOI":"10.1111\/j.1365-2826.2006.01512.x","type":"journal-article","created":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T17:23:30Z","timestamp":1165425810000},"page":"109-115","source":"Crossref","is-referenced-by-count":2,"title":["Mineralocorticoid Pretreatment Enhances Angiontensin II\u2010Induced Neuronal Excitation But Not Salt Drinking in Male Fischer Rats"],"prefix":"10.1111","volume":"19","author":[{"given":"S. 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