{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:51:19Z","timestamp":1791186679720,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:00:00Z","timestamp":1171929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p>The neural mechanisms controlling mate recognition and heterosexual partner preference are sexually differentiated by perinatal actions of sex steroid hormones. We previously showed that the most important action of oestrogen during prenatal development is to defeminise and, to some extent, masculinise brain and behaviour in mice. Female mice deficient in alpha\u2010foetoprotein (AFP) due to a targeted mutation in the <jats:italic>Afp<\/jats:italic> gene (AFP\u2010KO) do not show any female sexual behaviour when paired with an active male because they lack the protective action of AFP against maternal oestrogens. In the present study, we investigated whether odour preferences, another sexually differentiated trait in mice, are also defeminised and\/or masculinised in AFP\u2010KO females due to their prenatal exposure to oestrogens. AFP\u2010KO females of two background strains (<jats:italic>CD1<\/jats:italic> and <jats:italic>C57Bl\/6j<\/jats:italic>) preferred to investigate male over female odours when given the choice between these two odour stimuli in a Y\u2010maze, and thus remained very female\u2010like in this regard. Thus, the absence of lordosis behaviour in these females cannot be explained by a reduced motivation of AFP\u2010KO females to investigate male\u2010derived odours. Furthermore, the presence of a strong male\u2010directed odour preference in AFP\u2010KO females suggests a postnatal contribution of oestrogens to the development of preferences to investigate opposite\u2010sex odours.<\/jats:p>","DOI":"10.1111\/j.1365-2826.2007.01540.x","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:25:55Z","timestamp":1171985155000},"page":"329-334","source":"Crossref","is-referenced-by-count":18,"title":["Exposure to Oestrogen Prenatally Does Not Interfere with the Normal Female\u2010Typical Development of Odour Preferences"],"prefix":"10.1111","volume":"19","author":[{"given":"J.","family":"Bakker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"De 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