{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:38:16Z","timestamp":1792636696603,"version":"4.5.0"},"reference-count":78,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,6,22]],"date-time":"2007-06-22T00:00:00Z","timestamp":1182470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>Progestin\u2010facilitated lordosis of rodents is enhanced by activation of dopamine type 1 (D<jats:sub>1<\/jats:sub>) or GABA<jats:sub>A<\/jats:sub> receptors, their downstream G\u2010proteins, and\/or second messengers in the ventral tegmental area (VTA). We examined whether the ability of progestins to enhance lordosis via actions at D<jats:sub>1<\/jats:sub> and\/or GABA<jats:sub>A<\/jats:sub> receptors is contingent upon activation of the second messenger phospholipase C (PLC) and its associated kinase, protein kinase C (PKC), in the VTA. If the actions of progestins through D<jats:sub>1<\/jats:sub> and GABA<jats:sub>A<\/jats:sub> receptors in the VTA are mediated through PLC and PKC, then inhibiting PLC formation (Experiment 1) or blocking PKC (Experiment 2) should reduce progestin\u2010facilitated lordosis and its enhancement by D<jats:sub>1<\/jats:sub> (SKF38393) or GABA<jats:sub>A<\/jats:sub> (muscimol) receptor agonists. In Experiment 1, ovariectomised hamsters, primed with oestradiol (10\u2003\u00b5g; h\u20030)\u2003+\u2003progesterone (100\u2003\u00b5g; h\u200345), were pretested for lordosis and motor behaviour (h\u200348) and then infused with the PLC inhibitor, U73122 (400\u2003n<jats:sc>M<\/jats:sc>\/side), or vehicle. Thirty minutes later, hamsters were retested and then received infusions of SKF38393 (100\u2003ng\/side), muscimol (100\u2003ng\/side), or vehicle to the VTA. Hamsters were post\u2010tested for lordosis and motor behaviour 30\u2003min later. In Experiment 2, a similar protocol was utilised except that instead of the PLC inhibitor hamsters were infused with the PKC inhibitor, bisindolylmaleimide (75\u2003n<jats:sc>M<\/jats:sc>\/side). Systemic progesterone, SKF38393\u2010, and muscimol\u2010facilitated lordosis was attenuated by infusion of the PLC inhibitor, U73122, or the PKC inhibitor, bisindolylmaleimide, compared to vehicle to the VTA. Thus, the actions of progestins in the VTA to enhance lordosis through D<jats:sub>1<\/jats:sub> and\/or GABA<jats:sub>A<\/jats:sub> may include downstream activity of PLC and PKC.<\/jats:p>","DOI":"10.1111\/j.1365-2826.2007.01580.x","type":"journal-article","created":{"date-parts":[[2007,6,22]],"date-time":"2007-06-22T20:01:34Z","timestamp":1182542494000},"page":"717-724","source":"Crossref","is-referenced-by-count":9,"title":["In the Ventral Tegmental Area, the Membrane\u2010Mediated Actions of Progestins for Lordosis of Hormone\u2010Primed Hamsters Involve Phospholipase C and Protein Kinase C"],"prefix":"10.1111","volume":"19","author":[{"given":"C. A.","family":"Frye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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