{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T15:37:11Z","timestamp":1759073831555,"version":"3.38.0"},"reference-count":178,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T00:00:00Z","timestamp":1318896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>Steroid hormones, such as progesterone., are typically considered to be primarily secreted by the gonads (albeit adrenals can also be a source) and to exert their actions through cognate intracellular progestin receptors (PRs). Through its actions in the midbrain ventral tegmental Area (VTA), progesterone mediates appetitive (exploratory, anxiety, social approach) and consummatory (social, sexual) aspects of rodents\u2019 mating behaviour. However, progesterone and its natural metabolites (\u2018progestogens\u2019) are produced in the midbrain VTA independent of peripheral sources and midbrain VTA of adult rodents is devoid of intracellular PRs. One approach that we have used to understand the effects of progesterone and mechanisms in the VTA for mating is to manipulate the actions of progesterone in the VTA and to examine effects on lordosis (the posture female rodents assume for mating to occur). This review focuses on the effects and mechanisms of progestogens to influence reproduction and related processes. The actions of progesterone and its 5\u03b1\u2010reduced metabolite and neurosteroid, 5\u03b1\u2010pregnan\u20103\u03b1\u2010ol\u201020\u2010one (3\u03b1,5\u03b1\u2010THP; allopregnanolone) in the midbrain VTA to facilitate mating are described. The findings that 3\u03b1,5\u03b1\u2010THP biosynthesis in the midbrain occurs with mating are discussed. Evidence for the actions of 3\u03b1,5\u03b1\u2010THP in the midbrain VTA via nontraditional steroid targets is summarised. The broader relevance of these actions of 3\u03b1,5\u03b1\u2010THP for aspects of reproduction, beyond lordosis, is summarised. Finally, the potential role of the pregnane xenobiotic receptor in mediating 3\u03b1,5\u03b1\u2010THP biosynthesis in the midbrain is introduced.<\/jats:p>","DOI":"10.1111\/j.1365-2826.2011.02180.x","type":"journal-article","created":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T13:36:20Z","timestamp":1308749780000},"page":"961-973","source":"Crossref","is-referenced-by-count":22,"title":["Novel Substrates for, and Sources of, Progestogens for Reproduction"],"prefix":"10.1111","volume":"23","author":[{"given":"Cheryl Anne","family":"Frye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,18]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"1","article-title":"Steroid hormone receptors","volume":"34","author":"Baulieu EE","year":"1980","journal-title":"Expos Annu Biochim Med"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0248-4900(91)90045-O"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1999.0188"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.71062231.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(92)90025-A"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.5.1003"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.6.1347506"},{"key":"e_1_2_8_9_2","first-page":"395","volume-title":"Hormones\/Behavior Relations of Clinical Importance","author":"Frye CA","year":"2009"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.06.013"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2006.06.005"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0320507"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)91332-M"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.05.063"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.21.12208"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80900-9"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3703"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.2001.1674"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(01)00119-9"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(96)00195-1"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1286.040"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2007.03.027"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(99)00085-6"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)02084-1"},{"key":"e_1_2_8_25_2","first-page":"188","article-title":"Progesterone turnover to its 5\u03b1\u2010reduced metabolites in the ventral tegmental area of the midbrain is essential for initiating social and affective behavior and progesterone metabolism in female rats","volume":"34","author":"Frye CA","year":"2011","journal-title":"J Endocrinol Invest"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2004-0480"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901700302"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6297008"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.67.2.501"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1286.023"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2004.04.007"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-217-44252"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/153537020322800201"},{"key":"e_1_2_8_34_2","doi-asserted-by":"crossref","first-page":"19513","DOI":"10.1016\/S0021-9258(18)41805-4","article-title":"Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation","volume":"267","author":"Allan GF","year":"1992","journal-title":"J Biol Chem"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.1.72"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(91)90046-X"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(03)00129-6"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1210\/mend.11.11.0006"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.47.31317"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2010.09.006"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(99)00020-0"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.115.5.1118"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(85)90006-X"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.135.4.1409"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.10.12.1728"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90359-4"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-03-01766.1994"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(93)90158-L"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.47.31308"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200205070-00018"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2002.00809.x"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199812210-00001"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(00)00497-5"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(00)00410-X"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(02)00845-6"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.01088.x"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(92)90179-F"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(92)90396-Z"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(93)90072-5"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.1994.1043"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2008.02.001"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(87)90395-0"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod57.4.693"},{"key":"e_1_2_8_64_2","doi-asserted-by":"crossref","first-page":"12163","DOI":"10.1016\/S0021-9258(19)38326-7","article-title":"Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms","volume":"265","author":"Kastner P","year":"1990","journal-title":"Biol Chem"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0713"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/253357a0"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1283"},{"key":"e_1_2_8_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2008.01.001"},{"key":"e_1_2_8_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2008.05.019"},{"key":"e_1_2_8_70_2","doi-asserted-by":"publisher","DOI":"10.2741\/A345"},{"key":"e_1_2_8_71_2","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/S0021-9258(19)40024-0","article-title":"Progesterone and 17\u03b1\u2010hydroxyprogesterone. Novel stimulators of calcium influx in human sperm","volume":"265","author":"Blackmore P","year":"1990","journal-title":"J Biol Chem"},{"key":"e_1_2_8_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2004.05.013"},{"key":"e_1_2_8_73_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.1.8"},{"key":"e_1_2_8_74_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod54.5.993"},{"key":"e_1_2_8_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2005.02.010"},{"key":"e_1_2_8_76_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2006-0256"},{"key":"e_1_2_8_77_2","first-page":"347","article-title":"Regulation of Ca2+ and cyclic AMP during the first meiotic division in amphibian oocytes by progesterone","volume":"6","author":"Kostellow A","year":"1980","journal-title":"J Cyclic Nucleotide Res"},{"key":"e_1_2_8_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(01)00180-5"},{"key":"e_1_2_8_79_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1580121"},{"key":"e_1_2_8_80_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2422758"},{"key":"e_1_2_8_81_2","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1210\/endo.142.10.8451","article-title":"Direct regulation of postnatal GnRH neurons by the progesterone derivative allopregnanolone in the mouse","volume":"142","author":"Sim J","year":"2001","journal-title":"Endocrinology"},{"key":"e_1_2_8_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2005.02.012"},{"key":"e_1_2_8_83_2","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-07-0317"},{"key":"e_1_2_8_84_2","first-page":"89","article-title":"Hypothalamic output controlling reticulospinal and vestibulospinal systems important for emotional behavior","volume":"19","author":"Schwartz\u2010Giblin S","year":"1985","journal-title":"Int J Neurol"},{"key":"e_1_2_8_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(94)90036-1"},{"key":"e_1_2_8_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00727-8"},{"key":"e_1_2_8_87_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-106-1-192"},{"key":"e_1_2_8_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(78)90102-8"},{"key":"e_1_2_8_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(00)00242-4"},{"key":"e_1_2_8_90_2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3758\/BF03330633","article-title":"Intravenous progesterone elicits a more rapid induction of lordosis in rats than does SKF38393","volume":"28","author":"Frye CA","year":"2000","journal-title":"Psychobiology"},{"key":"e_1_2_8_91_2","first-page":"924","article-title":"Tectoreticular neuronal activity associated with behavior and progesterone action during the induction of lordosis responding in hamsters","volume":"16","author":"Rose JD","year":"1990","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_8_92_2","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.1994.1042"},{"key":"e_1_2_8_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/0018-506X(91)90036-H"},{"key":"e_1_2_8_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90233-Y"},{"key":"e_1_2_8_95_2","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.1996.0069"},{"key":"e_1_2_8_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2006.07.033"},{"key":"e_1_2_8_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.06.015"},{"key":"e_1_2_8_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)01132-9"},{"key":"e_1_2_8_99_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2016-3"},{"key":"e_1_2_8_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2007.01.005"},{"key":"e_1_2_8_101_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1143-6"},{"key":"e_1_2_8_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01399-5"},{"key":"e_1_2_8_103_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00383.2010"},{"key":"e_1_2_8_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2009.07.006"},{"key":"e_1_2_8_105_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0149"},{"key":"e_1_2_8_106_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0436133100"},{"key":"e_1_2_8_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(86)90013-6"},{"key":"e_1_2_8_108_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb09830.x"},{"key":"e_1_2_8_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(92)90022-P"},{"key":"e_1_2_8_110_2","first-page":"399","article-title":"Inhibition of 5\u03b1\u2010reductase enzyme or GABA(A) receptors in the VMH and the VTA attenuates progesterone\u2010induced sexual behavior in rats and hamsters","volume":"24","author":"Frye CA","year":"2001","journal-title":"J Endocrinol Invest"},{"key":"e_1_2_8_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(92)90044-G"},{"key":"e_1_2_8_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(93)90308-G"},{"key":"e_1_2_8_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2006.04.001"},{"key":"e_1_2_8_114_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.1999.00367.x"},{"key":"e_1_2_8_115_2","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0022-5347(25)00332-5","article-title":"Structure\u2010activity relationships for steroid interaction with the gamma\u2010aminobutyric acidA receptor complex","volume":"241","author":"Harrison NL","year":"1987","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_116_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1703"},{"key":"e_1_2_8_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)00096-4"},{"key":"e_1_2_8_118_2","first-page":"207","article-title":"A putative receptor for neurosteroids on the GABAA receptor complex: the pharmacological properties and therapeutic potential of epalons","volume":"9","author":"Gee KW","year":"1995","journal-title":"Crit Rev Neurobiol"},{"key":"e_1_2_8_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2003.09.001"},{"key":"e_1_2_8_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(87)90094-X"},{"key":"e_1_2_8_121_2","doi-asserted-by":"publisher","DOI":"10.1358\/mf.2004.26.7.863737"},{"key":"e_1_2_8_122_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh125"},{"key":"e_1_2_8_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90627-4"},{"key":"e_1_2_8_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91535-O"},{"key":"e_1_2_8_125_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-19-08003.1998"},{"key":"e_1_2_8_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2003.08.099"},{"key":"e_1_2_8_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90285-4"},{"key":"e_1_2_8_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(94)00181-E"},{"key":"e_1_2_8_129_2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0026-895X(25)08656-0","article-title":"\u03b1\u2010Hydroxy\u20105\u03b1\u2010pregnan\u201020\u2010one sulfate: a negative modulator of the NMDA\u2010induced current in cultured neurons","volume":"46","author":"Park\u2010Chung M","year":"1994","journal-title":"Mol Pharmacol"},{"key":"e_1_2_8_130_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2000.00471.x"},{"key":"e_1_2_8_131_2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0026-895X(25)12923-4","article-title":"Pregnenolone sulfate: a positive allosteric modulator at the N\u2010methyl\u2010D\u2010aspartate receptor","volume":"40","author":"Wu FS","year":"1991","journal-title":"Mol Pharmacol"},{"key":"e_1_2_8_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(84)90519-8"},{"key":"e_1_2_8_133_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00966870"},{"key":"e_1_2_8_134_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-07-02623.1992"},{"key":"e_1_2_8_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(90)90216-M"},{"key":"e_1_2_8_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2004.04.014"},{"key":"e_1_2_8_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.02.013"},{"key":"e_1_2_8_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2003.08.002"},{"key":"e_1_2_8_139_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2008.01.020"},{"key":"e_1_2_8_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(97)00189-7"},{"key":"e_1_2_8_141_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.5.641"},{"key":"e_1_2_8_142_2","doi-asserted-by":"crossref","first-page":"067","DOI":"10.1523\/JNEUROSCI.20-09-03067.2000","article-title":"Neurosteroid modulation of GABA IPSCs is phosphorylation dependent","volume":"20","author":"F\u00e1ncsik A","year":"2000","journal-title":"J Neurosci"},{"key":"e_1_2_8_143_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.05.014"},{"key":"e_1_2_8_144_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2007.01580.x"},{"key":"e_1_2_8_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2006.03.006"},{"key":"e_1_2_8_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.07.027"},{"key":"e_1_2_8_147_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2008.07.002"},{"key":"e_1_2_8_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.09.028"},{"key":"e_1_2_8_149_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2006.01488.x"},{"key":"e_1_2_8_150_2","doi-asserted-by":"publisher","DOI":"10.1159\/000082752"},{"key":"e_1_2_8_151_2","doi-asserted-by":"publisher","DOI":"10.1159\/000100510"},{"key":"e_1_2_8_152_2","doi-asserted-by":"publisher","DOI":"10.1159\/000096051"},{"key":"e_1_2_8_153_2","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.120.2.281"},{"key":"e_1_2_8_154_2","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.01208"},{"key":"e_1_2_8_155_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.11.004"},{"key":"e_1_2_8_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(94)00548-6"},{"key":"e_1_2_8_157_2","doi-asserted-by":"publisher","DOI":"10.1159\/000068338"},{"key":"e_1_2_8_158_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2005.01342.x"},{"key":"e_1_2_8_159_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00764-1"},{"key":"e_1_2_8_160_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051628598"},{"key":"e_1_2_8_161_2","doi-asserted-by":"publisher","DOI":"10.1080\/10253890500159022"},{"key":"e_1_2_8_162_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0337642100"},{"key":"e_1_2_8_163_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2003.04.002"},{"key":"e_1_2_8_164_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000587"},{"key":"e_1_2_8_165_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03076-7"},{"key":"e_1_2_8_166_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-008-9718-5"},{"key":"e_1_2_8_167_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(00)00392-0"},{"key":"e_1_2_8_168_2","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.2002.1763"},{"key":"e_1_2_8_169_2","doi-asserted-by":"publisher","DOI":"10.3758\/CABN.1.3.287"},{"key":"e_1_2_8_170_2","doi-asserted-by":"publisher","DOI":"10.1530\/REP-08-0250"},{"key":"e_1_2_8_171_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2006.01494.x"},{"key":"e_1_2_8_172_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.08.031"},{"key":"e_1_2_8_173_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02977789"},{"key":"e_1_2_8_174_2","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701311351"},{"key":"e_1_2_8_175_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2007.02.003"},{"key":"e_1_2_8_176_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2004-0434"},{"key":"e_1_2_8_177_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.11.022"},{"key":"e_1_2_8_178_2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0026-895X(24)05623-2","article-title":"Pregnane X receptor up\u2010regulation of P\u2010glycoprotein expression and transport function at the blood\u2010brain barrier","volume":"66","author":"Bauer B","year":"2004","journal-title":"Mol Pharmacol"},{"key":"e_1_2_8_179_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2003.12.027"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2826.2011.02180.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2826.2011.02180.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T14:15:31Z","timestamp":1741270531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2826.2011.02180.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,18]]},"references-count":178,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1111\/j.1365-2826.2011.02180.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2826.2011.02180.x","archive":["Portico"],"relation":{},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"type":"print","value":"0953-8194"},{"type":"electronic","value":"1365-2826"}],"subject":[],"published":{"date-parts":[[2011,10,18]]}}}