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Regulated exocytosis of LDCVs is considered to involve the soluble N\u2010ethylmaleimide sensitive fusion protein attachment protein receptor (SNARE) complex [comprising vesicle associated membrane protein 2 (VAMP\u20102), syntaxin\u20101 and soluble N\u2010ethylmaleimide attachment protein\u201025 (SNAP\u201025)] and regulatory proteins [such as synaptotagmin\u20101, munc\u201018 and Ca<jats:sup>2+<\/jats:sup>\u2010dependent activator protein for secretion (CAPS\u20101)]. Using fluorescent immunocytochemistry and confocal microscopy, in both oxytocin and vasopressin neurones, we observed VAMP\u20102, SNAP\u201025 and syntaxin\u20101\u2010immunoreactivity in axon terminals. The somata and dendrites contained syntaxin\u20101 and other regulatory exocytosis proteins, including munc\u201018 and CAPS\u20101. However, the distribution of VAMP\u20102 and synaptotagmin\u20101 in the SON was limited to putative pre\u2010synaptic contacts because they co\u2010localised with synaptophysin (synaptic vesicle marker) and had no co\u2010localisation with either oxytocin or vasopressin. SNAP\u201025 immunoreactivity in the SON was limited to glial cell processes and was not detected in oxytocin or vasopressin somata\/dendrites. The present results indicate differences in the expression and localisation of exocytosis proteins between the axon terminals and somata\/dendritic compartment. The absence of VAMP\u20102 and SNAP\u201025 immunoreactivity from the somata\/dendrites suggests that there might be different SNARE protein isoforms expressed in these compartments. Alternatively, exocytosis of LDCVs from somata\/dendrites may use a different mechanism from that described by the SNARE complex theory.<\/jats:p>","DOI":"10.1111\/j.1365-2826.2011.02237.x","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T17:45:22Z","timestamp":1318355122000},"page":"629-641","source":"Crossref","is-referenced-by-count":43,"title":["Expression of Exocytosis Proteins in Rat Supraoptic Nucleus Neurones"],"prefix":"10.1111","volume":"24","author":[{"given":"V.","family":"Tobin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Lelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Onaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q. 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