{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T09:39:24Z","timestamp":1775986764815,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T00:00:00Z","timestamp":1334793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>P\u2010glycoprotein (P\u2010gp), an efflux transporter localised in the blood\u2013brain barrier, limits the access of multiple xenobiotics to the central nervous system. Whether it is also implemented in the transport of the endogenous glucocorticoid corticosterone is a matter of debate. The P\u2010gp knockout mouse model [abcb1a\/b (\u2212\/\u2212)] has been shown to differ in the functioning of the hypothalamic\u2010pituitary adrenal (HPA) axis. In the present study, we investigated the behaviour of abcb1a\/b (\u2212\/\u2212) and wild\u2010type mice with respect to stress\u2010related tests and the effects of corticosterone. Behavioural activities were assessed in the open field (OF) test for 4\u2003days, and in the forced swimming test (FST) and tail suspension test (TST) under na\u00efve and stressed conditions. The FST was also conducted after exogenous corticosterone injection (0.25 and 2.5\u2003mg\/kg). Moreover, the elevated plus maze test and the RotaRod test (RotaRod Advanced; TSE Systems, Bad Homburg, Germany) were assessed. Brain corticosterone levels were determined by an immunoassay and expression of glucocorticoid receptors by western blot analysis. Abcb1a\/1b (\u2212\/\u2212) mice showed significantly decreased brain corticosterone levels and elevated glucocorticoid receptor expression. Behavioural analysis revealed a significantly decreased activity in the OF test on the first 2\u2003days in abcb1a\/1b (\u2212\/\u2212) mice compared to wild\u2010type mice, although the differences disappeared under habituation. Immobility time in the FST was significantly decreased in abcb1a\/1b (\u2212\/\u2212) mice under basal and under stressed conditions, whereas immobility in the TST was significantly elevated in these mice under all conditions. Injection of exogenous corticosterone resulted in significant reductions of immobility in the FST in abcb1a\/1b (\u2212\/\u2212) mice, whereas wild\u2010type mice did not respond to the same doses. There were no differences in the elevated plus maze test and RotaRod test. The results obtained in the present study demonstrate that a P\u2010gp deficiency has an impact on the stress\u2010related behaviour, possibly as a result of differences in HPA axis\u2010feedback regulation.<\/jats:p>","DOI":"10.1111\/j.1365-2826.2012.02278.x","type":"journal-article","created":{"date-parts":[[2012,2,17]],"date-time":"2012-02-17T15:49:04Z","timestamp":1329493744000},"page":"809-817","source":"Crossref","is-referenced-by-count":11,"title":["Behavioural Consequences of P\u2010Glycoprotein Deficiency in Mice, with Special Focus on Stress\u2010Related Mechanisms"],"prefix":"10.1111","volume":"24","author":[{"given":"Y.","family":"Schoenfelder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Hiemke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,19]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(98)00085-4"},{"key":"e_1_2_7_3_2","first-page":"1443","article-title":"The impact of P\u2010glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A\/1B knockout mouse model","volume":"34","author":"Doran A","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.11.067"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:PHAM.0000033017.52484.81"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(01)00564-2"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(96)00063-9"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118699"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.8.4028"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1211\/0022357043969"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00074-X"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.109.061754"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57867"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25247"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1993.54"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2002.00836.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","first-page":"24248","DOI":"10.1016\/S0021-9258(18)35757-0","article-title":"Human P\u2010glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone","volume":"267","author":"Ueda K","year":"1992","journal-title":"J Biol Chem"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300257"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301389"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0041"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.6.8213"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(00)00159-7"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(00)00352-9"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb12982.x"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(68)90174-1"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2009.02.002"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(85)90031-7"},{"key":"e_1_2_7_28_2","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt RD","year":"1977","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.03.009"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0103"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.12.011"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.11.009"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2010.06.010"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2148-5"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.19.3.269"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-5926fje"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2010.08.017"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.2527\/jas1983.5716"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1996.tb01264.x"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1080\/10253890701821081"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(94)90093-0"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2009.04.014"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01088-X"},{"key":"e_1_2_7_44_2","first-page":"185","article-title":"Implication of the hypothalamic\u2013pituitary\u2013adrenal axis in the physiopathology of depression","volume":"29","author":"Barden N","year":"2004","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(05)80230-1"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001457"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.10.045"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0554"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.108.023721"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.3.1346"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(97)00035-7"},{"key":"e_1_2_7_52_2","first-page":"1008","article-title":"Effect of two behavioural tests on corticosterone level in plasma of mice lacking the noradrenaline transporter","volume":"60","author":"Solich J","year":"2008","journal-title":"Pharmacol Rep"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.046532"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2826.2012.02278.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2826.2012.02278.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T10:28:17Z","timestamp":1697365697000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2826.2012.02278.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,19]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1365-2826.2012.02278.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2826.2012.02278.x","archive":["Portico"],"relation":{},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,19]]}}}