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We studied the organisation of tyrosine hydroxylase (TH; a marker for dopamine) and isotocin neurones in the preoptic area (POA) and hypothalamus of the catfish, <jats:italic>Clarias batrachus<\/jats:italic> and its implication in the regulation of luteinising hormone (LH) cells in the pituitary. Nucleus preopticus periventricularis (NPP), a major dopaminergic centre in the brain, consists of anterior (NPPa) and posterior (NPPp) subdivisions. Using retrograde neuronal tracing, we found that majority of the DA neurones in NPPa, but none from NPPp, project to the pituitary. The nucleus preopticus (NPO) of <jats:italic>C.\u00a0batrachus<\/jats:italic> contains a conspicuous assemblage of large isotocin\u2010positive neurones. It consists of a paraventricular subdivision (NPOpv) located on either side of the third ventricle and lies roughly sandwiched between the dopaminergic neurones of NPPa and NPPp. An additional subset of isotocin neurones was located above the optic chiasm in the supraoptic subdivision of the NPO (NPOso). Isotocin\u2010containing neurones in both the subdivisions of NPO were densely innervated by DA fibres. Superfusion of the POA\u2010containing brain slices with DA D<jats:sub>1<\/jats:sub>\u2010like receptor agonist (SKF\u201038393) resulted in significant increase in isotocin immunoreactivity in the NPOpv neurones; NPOso neurones did not respond. However, treatment with DA D<jats:sub>2<\/jats:sub>\u2010like receptor agonist (quinpirole) reduced isotocin immunoreactivity in the NPOso, but not in the NPOpv. Thus, DA appears to differentially regulate the components of isotocinergic system. Isotocin fibres extend to the pituitary and terminate on LH cells and the superfused pituitary slices treated with isotocin caused significant reduction in LH\u03b2\u2010immunoreactivity. An elaborate interplay between the DA and isotocin systems appears to be an important component of the LH regulatory system.<\/jats:p>","DOI":"10.1111\/j.1365-2826.2012.02350.x","type":"journal-article","created":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T14:45:38Z","timestamp":1338993938000},"page":"1398-1411","source":"Crossref","is-referenced-by-count":24,"title":["Interaction between Dopamine\u2010 and Isotocin\u2010Containing Neurones in the Preoptic Area of the Catfish, <i>Clarias batrachus<\/i>: Role in the Regulation of Luteinising Hormone Cells"],"prefix":"10.1111","volume":"24","author":[{"given":"U.","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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