{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:56:36Z","timestamp":1785466596373,"version":"3.56.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>The renin\u2013angiotensin\u2013aldosterone system makes a critical contribution to body fluid homeostasis, and abnormalities in this endocrine system have been implicated in certain forms of hypertension. The peptide hormone angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (Ang<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>) regulates hydromineral homeostasis and blood pressure by acting on both peripheral and brain targets. In the brain, Ang<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> binds to the angiotensin type 1 receptor (<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>1R) to stimulate thirst, sodium appetite and both arginine vasopressin (<jats:styled-content style=\"fixed-case\">AVP<\/jats:styled-content>) and oxytocin (<jats:styled-content style=\"fixed-case\">OT<\/jats:styled-content>) secretion. The present study used an experimental model of endogenous Ang<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> to examine the role of p44\/42 mitogen\u2010activated protein kinase (<jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>) as a signalling mechanism to mediate these responses. Animals were given a combined treatment of furosemide and a low dose of captopril (furo\/cap), comprising a diuretic and an angiotensin\u2010converting enzyme inhibitor, respectively, to elevate endogenous Ang<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> levels in the brain. Furo\/cap induced p44\/42 <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content> activation in key brain areas that express <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>1R, and this effect was reduced with either a centrally administered <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>1R antagonist (irbesartan) or a p44\/42 <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content> inhibitor (U0126). Additionally, furo\/cap treatment elicited water and sodium intake, and irbesartan markedly reduced both of these behaviours. Central injection of U0126 markedly attenuated furo\/cap\u2010induced sodium intake but not water intake. Furthermore, p44\/42 <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content> signalling was not necessary for either furo\/cap\u2010 or exogenous Ang<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">AVP<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">OT<\/jats:styled-content> release. Taken together, these results indicate that p44\/42 <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content> is required for Ang<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2010induced sodium appetite but not thirst or neurohypophysial secretion. This result may allow for the discovery of more specific downstream targets of p44\/42 <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content> to curb sodium appetite, known to exacerbate hypertension, at the same time as leaving thirst and neurohypophysial hormone secretion undisturbed.<\/jats:p>","DOI":"10.1111\/j.1365-2826.2012.02376.x","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T06:21:10Z","timestamp":1345702870000},"page":"97-106","source":"Crossref","is-referenced-by-count":18,"title":["Endogenous Angiotensin <scp>II<\/scp>\u2010induced p44\/42 Mitogen\u2010Activated Protein Kinase Activation Mediates Sodium Appetite but not Thirst or Neurohypophysial Secretion in Male Rats"],"prefix":"10.1111","volume":"25","author":[{"given":"L. 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