{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:08:50Z","timestamp":1791198530783,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>Data from transgenic mouse models of <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>untington's disease (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) suggest that dysfunction of the hypothalamic infundibular nucleus (INF) (in rodents, the arcuate nucleus) may contribute to unintended weight loss and insatiable appetite among <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients. Using post\u2010mortem paraffin\u2010embedded tissue, we assessed the total number of <jats:styled-content style=\"fixed-case\">INF<\/jats:styled-content> neurones by thionin staining and four major regulatory neuropeptides in the INF of <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients by immunocytochemistry and <jats:italic>in situ<\/jats:italic> hybridisation. In <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients, the total number of neurones in the INF was unchanged compared to control subjects (P\u00a0=\u00a00.92), whereas it contained over 30% less neuropeptide <jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content>\u2010immunoreactive (IR) neurones (P\u00a0=\u00a00.016), as well as reduced peptide levels, in fibres to the paraventricular and ventromedial nucleus (P\u00a0=\u00a00.003, P\u00a0=\u00a00.005, respectively). Conversely, neuropeptide <jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content> m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression levels were increased three\u2010fold (P\u00a0=\u00a00.047). No changes were observed in the number of neurones immunoreactive for \u03b1\u2010melanocyte\u2010stimulating hormone, agouti\u2010related peptide, and cocaine\u2010 and amphetamine\u2010regulated transcript (P\u00a0\u2265\u00a00.17). Our findings suggest changes in the pathology of the INF neuropeptide <jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content>\u2010expressing neurones in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients without changes in other (an)orexigenic neuropeptides and without neuronal cell loss. These findings indicate that unintended weight loss in patients suffering from this disease may be partly a result of neuropeptidergic alterations in the hypothalamic infundibular nucleus.<\/jats:p>","DOI":"10.1111\/j.1365-2826.2012.02379.x","type":"journal-article","created":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T06:45:35Z","timestamp":1346222735000},"page":"198-205","source":"Crossref","is-referenced-by-count":16,"title":["Neuropeptide Alterations in the Infundibular Nucleus of Huntington's Disease Patients"],"prefix":"10.1111","volume":"25","author":[{"given":"D. J.","family":"van Wamelen","sequence":"first","affiliation":[{"name":"Netherlands Institute for Neuroscience an Institute of the Royal Netherlands Academy of Arts and Sciences Amsterdam The Netherlands"},{"name":"Department of Neurology Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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