{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:27:55Z","timestamp":1775064475567,"version":"3.50.1"},"reference-count":76,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>Postpartum depression (<jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>) affects approximately 15% of mothers after giving birth. A complete understanding of depression during the postpartum period has yet to be established, although disruptions in the hypothalamic\u2010pituitary\u2010adrenal axis and stress during the postpartum may be involved. To model these components in rats, we administered high corticosterone (<jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content>) postpartum, which increases immobility in the forced swim test (<jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>), and reduces maternal care, body weight and hippocampal cell proliferation in dams. The hippocampus is altered in response to chronic stress, exposure to high glucocorticoids and in major depression in humans. In the present study, we examined whether high <jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content> reduced dendritic complexity and spines in the <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>3 region of the hippocampus. Additionally, housing complexity was manipulated so that dams and litters were housed either with tubes (complex) or without tubes (impoverished) to investigate the consequences of new animal care regulations. Dams received 40\u00a0mg\/kg\/day of <jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content> or oil starting on day 2 postpartum for 23\u00a0days. Maternal behaviours were assessed on postpartum days 2\u20138 and dams were tested using the <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content> on days 21 and 22. Dams were killed on day 24 and brains were processed for Golgi impregnation. Pyramidal cells in the <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>3 subfield were traced using a camera lucida and analysed for branch points and dendritic complexity, as well as spine density and type on both basal and apical arbours. As previously established, high <jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content> postpartum reduced maternal care and increased immobility in the <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>, which is a measure of depressive\u2010like behaviour. High <jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content> postpartum reduced the complexity of basal arbours and increased mushroom spines on both apical and basal dendrites. Housing complexity had no effect on spines of <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>3 pyramidal cells but modest effects on cell morphology. These data show that chronic high <jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content> in postpartum females alters hippocampal morphology and may provide insight regarding the neurobiological consequences of high stress or <jats:styled-content style=\"fixed-case\">CORT<\/jats:styled-content> during the postpartum period, as well as be relevant for postpartum stress or depression.<\/jats:p>","DOI":"10.1111\/j.1365-2826.2012.02380.x","type":"journal-article","created":{"date-parts":[[2012,8,30]],"date-time":"2012-08-30T16:22:29Z","timestamp":1346343749000},"page":"119-130","source":"Crossref","is-referenced-by-count":68,"title":["Postpartum Corticosterone Administration Reduces Dendritic Complexity and Increases the Density of Mushroom Spines of Hippocampal <scp>CA<\/scp>3 Arbours in Dams"],"prefix":"10.1111","volume":"25","author":[{"given":"J. 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