{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:29:49Z","timestamp":1762100989511},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,11,2]],"date-time":"2009-11-02T00:00:00Z","timestamp":1257120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p><jats:bold>Summary\u2002<\/jats:bold> The aim of the present study was to determine in humans whether local anaesthesia (LA) or nociceptive stimulation of the periodontal ligaments affects the excitability of the face primary motor cortex (MI) related to the tongue and jaw muscles, as measured by transcranial magnetic stimulation (TMS). Twelve healthy volunteers (11 men, 1 woman, 25\u00b73\u2003\u00b1\u20034\u00b72\u2003years) participated in two 3\u2010h sessions separated by 7\u2003days. The LA carbocain or the nociceptive irritant capsaicin was randomly injected into the periodontal ligament of the lower right central incisor. In both sessions, TMS\u2013motor evoked potential (MEP) stimulus\u2013response curves and corticomotor maps were acquired for the tongue and masseter muscles before (baseline) and at 5, 30 and 60\u2003min post\u2010application of carbocain or capsaicin. Transcranial magnetic stimulation\u2013MEP stimulus\u2013response curves were also acquired at these time points for the first dorsal interosseous (FDI) as an internal control. Burning pain intensity and mechanical sensitivity ratings to a von Frey filament applied to the application site were recorded on an electronic visual analogue scale (VAS). All subjects reported a decreased mechanical sensitivity (<jats:sc>anova<\/jats:sc>: <jats:italic>P\u2003<\/jats:italic>=\u20030\u00b7004) in the LA session and a burning pain sensation (VAS peak pain: 6\u00b74\u2003\u00b1\u20031\u00b70) in the capsaicin session. No significant changes in cortical excitability of the MI, as reflected by TMS\u2013MEP stimulus\u2013response curves or corticomotor maps for the tongue, masseter or FDI were found between baseline and post\u2010injection for the LA (<jats:sc>anova<\/jats:sc>s: <jats:italic>P<\/jats:italic>\u2003&gt;\u20030\u00b722) or capsaicin (<jats:sc>anova<\/jats:sc>s: <jats:italic>P<\/jats:italic>\u2003&gt;\u20030\u00b716) sessions. These findings suggest that a transient loss or perturbation in periodontal afferent input to the brain from a single incisor is insufficient to cause changes in corticomotor excitability of the face MI, as measured by TMS in humans.<\/jats:p>","DOI":"10.1111\/j.1365-2842.2009.02016.x","type":"journal-article","created":{"date-parts":[[2009,11,2]],"date-time":"2009-11-02T09:32:16Z","timestamp":1257154336000},"page":"39-47","source":"Crossref","is-referenced-by-count":10,"title":["Effects of periodontal afferent inputs on corticomotor excitability in 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