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Glutamate effects that include neuronal damage and apoptosis following hypoxemia and apnea following microinjections in animal models are in part mediated via postjunctional <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>d<\/jats:sc>\u2010aspartate (NMDA) receptors. This was a double blind, randomized, placebo\u2010controlled single dose cross\u2010over study of the NMDA receptor antagonist AR\u2010R15896AR in 15 male patients with moderate to severe SDB. Seven patients received 120\u2003mg and eight patients received 350\u2003mg AR\u2010R15896AR or corresponding placebo (given by 2\u2003h infusion) starting half an hour before estimated sleep onset. AR\u2010R15896AR concentrations were in line with the predicting kinetic model. A standard polysomnographic montage was applied. Repeated plasma samples were obtained in nine patients for analysis of plasma glutamate. Glutamate concentration in plasma did not change overnight and was unrelated to severity of SDB. Overall AHI (apnea\u2013hypopnea index; primary efficacy variable) or investigated oxygen saturation variables were not significantly changed after AR\u2010R15896AR at either dosage level. Side effects were mostly confined to the higher dose level and included vivid dreams, nightmares as well as in two cases mild hallucinations. The previously postulated role of glutamate in SDB could not be confirmed after AR\u2010R15896AR induced NMDA\u2010receptor blockade.<\/jats:p>","DOI":"10.1111\/j.1365-2869.2005.00441.x","type":"journal-article","created":{"date-parts":[[2005,5,23]],"date-time":"2005-05-23T07:46:49Z","timestamp":1116834409000},"page":"149-155","source":"Crossref","is-referenced-by-count":16,"title":["A randomized placebo\u2010controlled trial of an NMDA receptor antagonist in sleep\u2010disordered breathing"],"prefix":"10.1111","volume":"14","author":[{"given":"STEFAN","family":"TORVALDSSON","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LUDGER","family":"GROTE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u00dcKSEL","family":"PEKER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HANS","family":"BASUN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAN","family":"HEDNER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1109\/10.983454"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.109.6.1490"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198210213071701"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00363-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.1202"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150200065"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.109.5.1269"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(97)01016-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90061-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00.16592100"},{"key":"e_1_2_6_12_1","first-page":"410","article-title":"Impact of obstructive sleep apnea and sleepiness on metabolic and cardiovascular risk factors in the Swedish Obese Subjects (SOS) Study","volume":"19","author":"Grunstein R. 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