{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:48:25Z","timestamp":1785944905377,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T00:00:00Z","timestamp":1147737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Central Sleep Apnoea (CSA) occurs commonly in heart failure. Adaptive servo\u2010ventilation (ASV) and deadspace (DS) have been shown in research settings to reverse CSA. The likely mechanism for this is the increase of PaCO<jats:sub>2<\/jats:sub> above the apnoeic threshold. However the role of increasing FiCO<jats:sub>2<\/jats:sub> on arousability remains unclear. To compare the effects of ASV and DS on sleep and breathing, in particular effects on Arousal Index (ArI), ten male patients with heart failure and CSA were studied during three nights with polysomnography plus measurements of PetCO<jats:sub>2<\/jats:sub>. The order of the interventions control (C), ASV and DS was randomized. ASV and DS caused similar reductions in apnoea\u2013hypopnoea index [(C) 30.0\u2003\u00b1\u20036.6, (ASV) 14.0\u2003\u00b1\u20033.8, (DS) 15.9\u2003\u00b1\u20034.7\u2003e\u2003h<jats:sup>\u22121<\/jats:sup>; both <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05]. However, DS was associated with decreased total sleep time compared with C (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.02) and increased spontaneous ArI compared to C and ASV (both <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01). Only DS was associated with increased \u0394PetCO<jats:sub>2<\/jats:sub> from resting wakefulness to eupnic sleep [(C) 2.1 \u2003\u00b1\u20030.9, (ASV) 1.3\u2003\u00b1\u20031.0, (DS) 5.6\u2003\u00b1\u20030.5\u2003mmHg; <jats:italic>P<\/jats:italic>\u2003=\u20030.01]. ASV and DS both stabilized ventilation however DS application also increased sleep fragmentation with negative impacts on sleep architecture. We speculate that this effect is likely to be mediated by increased PetCO<jats:sub>2<\/jats:sub> and respiratory effort associated with DS application.<\/jats:p>","DOI":"10.1111\/j.1365-2869.2006.00515.x","type":"journal-article","created":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T11:58:32Z","timestamp":1147780712000},"page":"199-205","source":"Crossref","is-referenced-by-count":59,"title":["Adaptive servo\u2010ventilation and deadspace: effects on central sleep apnoea"],"prefix":"10.1111","volume":"15","author":[{"given":"I.","family":"SZOLLOSI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"O'DRISCOLL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"DAYER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"COATS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Morrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. K.","family":"Simonds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12020414"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.3.9908040"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/142.2.295"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.21.2154"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.5.1551"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.11.1435"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.5.9810040"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.2.7633695"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-11-200606060-00004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.12.1574"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/sleep\/17.1.61","article-title":"Effect of inhaled 3% CO2 on Cheyne\u2013Stokes respiration in congestive heart failure","volume":"17","author":"Steens R. D.","year":"1994","journal-title":"Sleep"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080634"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1093\/sleep\/15.2.174","article-title":"EEG arousals: scoring and examples. A preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association","volume":"15","author":"Task Force of the American Sleep Disorders Association","year":"1992","journal-title":"Sleep"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.4.9908114"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.2.H722"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00870671"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.3.918"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2869.2006.00515.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2869.2006.00515.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T21:36:53Z","timestamp":1695850613000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2869.2006.00515.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,16]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1111\/j.1365-2869.2006.00515.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2869.2006.00515.x","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,16]]}}}