{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:59:18Z","timestamp":1761742758317,"version":"3.32.0"},"reference-count":68,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T00:00:00Z","timestamp":1147737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study makes use of control system model identification techniques to examine the relationship between thermoregulation and sleep regulation. Specifically, data\u2010based mechanistic (DBM) modelling is used to formulate and experimentally test the hypothesis, put forth by Gilbert<jats:italic>et\u00a0al.<\/jats:italic>[<jats:italic>Sleep Med. Rev.<\/jats:italic><jats:bold>8<\/jats:bold>(2004) 81], that there exists a connection between distal heat loss and sleepiness. Six healthy sleepers each spent three nights and the following day in the sleep laboratory: an adaptation, a cognitive arousal and a neutral testing day. In the cognitive arousal condition, a visit of a television camera crew took place and subjects were asked to be interviewed. During each of the three 25\u2010min driving simulator tasks per day, the distal\u2010to\u2010proximal gradient and the electroencephalogram are recorded. It is observed from these experimental data that there exists a feedback connection between thermoregulation and sleep. In addition to providing experimental evidence in support of the<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#b20\">Gilbert<jats:italic>et\u00a0al.<\/jats:italic>(2004)<\/jats:ext-link>hypothesis, the authors propose that the nature of the feedback connection is determined by the nature of sleep\/wake state (i.e. NREM sleep versus unwanted sleepiness in active subjects). Besides this, an individualized and time\u2010variant model for the linkage between thermoregulation and sleep onset is presented. This compact model feeds on real\u2010time data regarding distal heat loss and sleepiness and contains a physically meaningful parameter that delivers an individual\u2010 and time\u2010depending quantification of a well known biological features in the field of thermoregulation: the thermoregulatory error signal<jats:italic>T<\/jats:italic><jats:sub>hypo<\/jats:sub>(<jats:italic>t<\/jats:italic>)\u2212<jats:italic>T<\/jats:italic><jats:sub>set<\/jats:sub>(<jats:italic>t<\/jats:italic>). A validation of these physical\/biological features emphasizes the reliability and power of DBM in describing individual differences related to the sleep process.<\/jats:p>","DOI":"10.1111\/j.1365-2869.2006.00519.x","type":"journal-article","created":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T11:58:32Z","timestamp":1147780712000},"page":"183-198","source":"Crossref","is-referenced-by-count":15,"title":["Individualized and time\u2010variant model for the functional link between thermoregulation and sleep onset"],"prefix":"10.1111","volume":"15","author":[{"given":"STIJN","family":"QUANTEN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELKE","family":"DE VALCK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAYMOND","family":"CLUYDTS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEAN\u2010MARIE","family":"AERTS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DANIEL","family":"BERCKMANS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,16]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"267","volume-title":"Proceedings of the Second International Symposium on Information Theory","author":"Akaike H.","year":"1973"},{"key":"e_1_2_5_3_1","first-page":"R1240","article-title":"Neuronal discharge of preoptic\/anterior hypothalamic thermosensitive neurons: relation to NREM sleep","volume":"269","author":"Alam A. 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