{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:21:17Z","timestamp":1786926077746,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,11,17]],"date-time":"2006-11-17T00:00:00Z","timestamp":1163721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of the study was to examine the efficacy and safety of temazepam on nocturnal oxygenation and next\u2010day performance at altitude. A double\u2010blind, randomized, cross\u2010over trial was performed in Thirty\u2010three healthy volunteers. Volunteers took 10\u2003mg of temazepam and placebo in random order on two successive nights soon after arrival at 5000\u2003m, following a 17\u2010day trek from 410\u2003m. Overnight SaO<jats:sub>2<\/jats:sub> and body movements, and next\u2010day reaction time, maintenance of wakefulness and cognition were assessed. Compared with placebo, temazepam resulted in a reduction in periodic breathing from a median (range) of 16 (0\u201381.3)% of the night to 9.4 (0\u201379.6)% (<jats:italic>P<\/jats:italic>\u2003=\u20030.016, Wilcoxon's signed\u2010rank test), associated with a small but significant decrease in mean nocturnal SaO<jats:sub>2<\/jats:sub> from 78 (65\u201384)% to 76 (64\u201383)% (<jats:italic>P<\/jats:italic>\u2003=\u20030.013). There was no change in sleep latency (<jats:italic>P<\/jats:italic>\u2003=\u20030.40) or restlessness (<jats:italic>P<\/jats:italic>\u2003=\u20030.30). Temazepam had no adverse effect on next\u2010day reaction time [241 (201\u2013380)\u2003ms postplacebo and 242 (204\u2013386)\u2003ms post\u2010temazepam], maintenance of wakefulness (seven trekkers failed to maintain 40\u2003min of wakefulness postplacebo, and four post\u2010temazepam), cognition or acute mountain sickness. At high altitude temazepam reduces periodic breathing during sleep without an adverse effect on next\u2010day reaction time, maintenance of wakefulness or cognition. The 2% reduction in mean SaO<jats:sub>2<\/jats:sub> post\u2010temazepam is likely to be predominantly because of acclimatization, as by chance more trekkers took temazepam on the first night (19 versus 14). We conclude that at high altitude temazepam is effective in reducing periodic breathing, and is safe to use, without any adverse effect upon next\u2010day performance.<\/jats:p>","DOI":"10.1111\/j.1365-2869.2006.00558.x","type":"journal-article","created":{"date-parts":[[2006,11,17]],"date-time":"2006-11-17T13:41:18Z","timestamp":1163770878000},"page":"445-454","source":"Crossref","is-referenced-by-count":79,"title":["Temazepam at high altitude reduces periodic breathing without impairing next\u2010day performance: a randomized cross\u2010over double\u2010blind study"],"prefix":"10.1111","volume":"15","author":[{"given":"ANNABEL H.","family":"NICKOL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JULIETTE","family":"LEVERMENT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PAUL","family":"RICHARDS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PHILIPPA","family":"SEAL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GREG A.","family":"HARRIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JENIFER","family":"CLELAND","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GERALD","family":"DUBOWITZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAVID J.","family":"COLLIER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAMES","family":"MILLEDGE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOHN R.","family":"STRADLING","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARY J.","family":"MORRELL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.4_Pt_1.817"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000076723"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.3.9711033"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00015805"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/sleep\/16.6.529","article-title":"Benzodiazepines in congestive heart failure: effects of temazepam on arousability and Cheyne\u2013Stokes respiration","volume":"16","author":"Biberdorf D.","year":"1993","journal-title":"Sleep"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/8.1.11"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1986.tb00630.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/13.1.31"},{"key":"e_1_2_7_10_1","first-page":"217","article-title":"Clinical and physiologic heterogeneity of the central sleep apnea syndrome","volume":"134","author":"Bradley T.","year":"1986","journal-title":"Am. 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